TABLE OF CONTENTS
| 11 September 2013 | Volume 32, Issue 18 |  | | |  |  Have you seen?
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Click here for more information or to register for this conference today! | | | | |  | Have you seen? | Top | |  | |  Bacterial second messengers, cGMP and c-di-GMP, in a quest for regulatory dominance A novel signalling pathway links cGMP to the regulation of c-di-GMP synthesis and the control of biofilm formation and virulence in the plant pathogen Xanthomonas campestris. Mark Gomelsky and Michael Y Galperin The EMBO Journal (2013), 32, 2421 - 2423; 10.1038/emboj.2013.193 Abstract | Full text | PDF | Related article Published online: 20 August 2013 | | | |  Give what you can and keep what you need! Peroxisomes are tethered to the cortical ER in budding yeast and only free peroxisomes are transported into the bud during cell division. Inp1p acts as a molecular hinge, connecting peroxisomal to ER-located Pex3p. Wolfgang Girzalsky and Ralf Erdmann The EMBO Journal (2013), 32, 2424 - 2426; 10.1038/emboj.2013.180 Abstract | Full text | PDF | Related article Published online: 06 August 2013 | | | |  The SAMHD1 knockout mouse model: in vivo veritas? Retrovirus restriction and autoinflammatory disease roles of the nucleotide hydrolase SAMHD1 vary between humans and mice, revealing effects of species-specific differences in cellular dNTP pools. Ferdinand Roesch and Olivier Schwartz The EMBO Journal (2013), 32, 2427 - 2429; 10.1038/emboj.2013.190 Abstract | Full text | PDF | Related article Published online: 20 August 2013 | | Articles | Top | | | |  A cyclic GMP-dependent signalling pathway regulates bacterial phytopathogenesis EMBO Open In the plant pathogen X. campestris, the second messenger cGMP controls bacterial virulence and biofilm formation through direct regulation of XC_0249, a novel diguanylate cyclase that synthesises the signalling molecule cyclic di-GMP. Shi-Qi An, Ko-Hsin Chin, Melanie Febrer, Yvonne McCarthy, Jauo-Guey Yang, Chung-Liang Liu, David Swarbreck, Jane Rogers, J Maxwell Dow, Shan-Ho Chou and Robert P Ryan The EMBO Journal (2013), 32, 2430 - 2438; 10.1038/emboj.2013.165 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 July 2013 | | | |  An ER-peroxisome tether exerts peroxisome population control in yeast Peroxisomes are organelles involved in the β-oxidation of fatty acids and quench reactive oxygen species. Uniform peroxisome numbers are maintained in dividing budding yeast by tethering them to the ER in mother cells, while tetherless organelles are destined to daughter cells. Barbara Knoblach, Xuejun Sun, Nicolas Coquelle, Andrei Fagarasanu, Richard L Poirier and Richard A Rachubinski The EMBO Journal (2013), 32, 2439 - 2453; 10.1038/emboj.2013.170 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 July 2013 | | | |  SAMHD1-dependent retroviral control and escape in mice The triphosphohydrolase SAMHD1 restricts virus infection in vivo by limiting the availability of free dNTPs to block reverse transcription of retroviral genomes. Jan Rehwinkel, Jonathan Maelfait, Anne Bridgeman, Rachel Rigby, Bruce Hayward, Rachel A Liberatore, Paul D Bieniasz, Greg J Towers, Luis F Moita, Yanick J Crow, David T Bonthron and Caetano Reis e Sousa The EMBO Journal (2013), 32, 2454 - 2462; 10.1038/emboj.2013.163 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 19 July 2013 | | | |  Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells The first mouse model specifically lacking the catalytic domain of the linear ubiquitin chain assembly complex reveals critical HOIP roles in NF-κB activation by TNF receptors, but surprisingly not by B-cell receptor. Yoshiteru Sasaki, Soichi Sano, Masaki Nakahara, Shigeo Murata, Kohei Kometani, Yuichi Aiba, Shinji Sakamoto, Yoshihiro Watanabe, Keiji Tanaka, Tomohiro Kurosaki and Kazuhiro Iwai The EMBO Journal (2013), 32, 2463 - 2476; 10.1038/emboj.2013.184 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 August 2013 | | | |  Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis A key transducer of the unfolded protein response is required for pro-inflammatory cytokine production in macrophages, being regulated by a novel TLR/TRAF6/ubiquitination axis that controls IRE1α phosphorylation. Quan Qiu, Ze Zheng, Lin Chang, Yuan-Si Zhao, Can Tan, Aditya Dandekar, Zheng Zhang, Zhenghong Lin, Ming Gui, Xiu Li, Tongshuai Zhang, Qingfei Kong, Hulun Li, Sha Chen, An Chen, Randal J Kaufman, Wei-Lei Yang, Hui-Kuan Lin, Donna Zhang, Harris Perlman, Edward Thorp, Kezhong Zhang and Deyu Fang The EMBO Journal (2013), 32, 2477 - 2490; 10.1038/emboj.2013.183 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 August 2013 | | | |  PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7 The protein phosphatase 2A holoenzyme including the Bα regulatory subunit is shown for the first time to play a specific role during development. PP2A-Bα regulates HDAC7, which in turn modulates endothelial cell cytoskeleton dynamics through ArgBP2 to stabilize blood vessel lumens. Maud Martin, Ilse Geudens, Jonathan Bruyr, Michael Potente, Anouk Bleuart, Marielle Lebrun, Nicolas Simonis, Christophe Deroanne, Jean-Claude Twizere, Philippe Soubeyran, Paul Peixoto, Denis Mottet, Veerle Janssens, Wolf-Karsten Hofmann, Filip Claes, Peter Carmeliet, Richard Kettmann, Holger Gerhardt and Franck Dequiedt The EMBO Journal (2013), 32, 2491 - 2503; 10.1038/emboj.2013.187 Abstract | Full text | PDF | Supp. info.| Review Process File Published online: 16 August 2013 | | | |  Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine Engagement of the RING ubiquitin ligase gp78 with its E2 Ube2g2 involves distinct allosteric mechanisms that enhance their affinity for ubiquitin–substrate conjugation, and reduce it to promote E2-ubiquitin recharging. Ranabir Das, Yu-He Liang, Jennifer Mariano, Jess Li, Tao Huang, Aaren King, Sergey G Tarasov, Allan M Weissman, Xinhua Ji and R Andrew Byrd The EMBO Journal (2013), 32, 2504 - 2516; 10.1038/emboj.2013.174 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 August 2013 | | | |  NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function Dynein anchoring at the cell cortex by a NuMA-containing complex is not only required for correct metaphase spindle positioning, but also important for anaphase B spindle elongation. Sachin Kotak, Coralie Busso and Pierre Gönczy The EMBO Journal (2013), 32, 2517 - 2529; 10.1038/emboj.2013.172 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 August 2013 | | | | Advertisement | | | | | | | Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. 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