Drug Discovery@nature.com 1 July 2013

Advertisement iCell® & MyCell® Human Cells Reinvent Discovery Research Ready-made iPSC-derived cells: Cardiomyocytes, neurons, hepatocytes, endothelial cells, and more Made-to-order cells from your donor samples or CDI disease cell lines including cardiomyopathies / arrhythmias, neurological disorders, muscular dystrophies, and more Enabling disease modeling, cell therapy, tissue engineering, and more TABLE OF CONTENTS 1 July 2013 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement FREE Nature Collection: Chronic Pain This Nature Collection brings together articles that highlight recent advances towards understanding the risk factors and mechanisms that underlie chronic pain, and developing effective, non-addictive treatments for this highly prevalent condition. FREE online until October 2013. Produced with support from The NIH Pain Consortium      News Top Silver makes antibiotics thousands of times more effective doi:10.1038/nature.2013.13232 Ancient antimicrobial treatment could help to solve modern bacterial resistance. Full Text Blocking boozy memories reduces risk of relapse doi:10.1038/nature.2013.13252 Molecule associated with learning and memory could be key to treating alcoholism. Full Text Simple molecule prevents mole rats from getting cancer doi:10.1038/nature.2013.13236 Sugar matrix surrounding cells traps would-be tumours in long-lived mammal. Full Text Inducing translation doi:10.1038/nbt.2602 The field of induced pluripotent stem cells is barely seven years old, but already three groups are close to launching clinical trials. Ken Garber looks into the prospects and perils. Full Text Analysis Top Interfacing with Ras doi:10.1038/scibx.2013.588 A German team has identified a compound that disrupts a protein-protein interaction that localizes K-Ras to the cell membrane, thus selectively inhibiting tumor growth. The interface provides a new small molecule binding site for the handful of companies and academics working on ways to tackle the previously undruggable Ras family. Full Text RON's new role doi:10.1038/scibx.2013.507 A team has shown that inhibiting the kinase RON could fight cancer metastasis by stimulating an antitumour immune response, building a case for focusing drug discovery efforts specifically against RON, which has long been neglected in favour of its relative, MET. Full Text Research Highlights Top Inflammatory disorders: Targeting TRAFs tames inflammation doi:10.1038/nrd4029 Inhibition of tumour necrosis factor receptor-associated factors (TRAFs) through FBX03 could represent a novel potential anti-inflammatory therapeutic strategy. Full Text G protein-coupled receptors: Pioneering Frizzled family receptor structure solved doi:10.1038/nrd4030 A crystal structure of the human Smoothened (SMO) receptor — an essential component of the Hedgehog signalling pathway — bound to an antitumour compound has been solved. Full Text Analgesia: A new player in neuropathic pain pathogenesis doi:10.1038/nrd4031 The WNT family of proteins, which are involved in the regulation of cellular processes during nervous system development, have a key role in the pathogenesis of neuropathic pain. Full Text Research & Reviews Top Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases doi:10.1038/nrd4010 Although nucleoside analogues have been used clinically for decades, efforts continue to improve response rates and reduce side effects. This article highlights recent progress in the development of new nucleoside and nucleotide analogues for cancer and viral diseases. Full Text The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer doi:10.1038/nrc3521 This article discusses deep sequencing studies indicating that nearly 20% of human tumours harbour mutations in G-protein-coupled receptors (GPCRs) and the implications for GPCRs as therapeutic targets in oncology. Full Text The good, the bad and the ugly — TFH cells in human health and disease doi:10.1038/nri3447 An increasing number of studies have highlighted new aspects of the differentiation and function of T follicular helper (TFH) cells in disease, which might represent targets for novel therapeutics. Full Text Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling doi:10.1038/nature12205 Interfering with binding of PDEδ to KRAS with small molecules provides a novel opportunity to suppress oncogenic RAS signalling by altering its localization to endomembranes. Full Text Drug Discovery JOBS of the week Research Laboratory Head (M / F) Cancer Drug Discovery Boehringer Ingelheim RCV GmbH & Co KG Postdoctoral Training Fellow (Synthetic Chemist / PET Radiochemist) Institute of Cancer Reseach Senior Research Officer / Fellow The University of Queensland, Institute for Molecular Bioscience Postdoctoral Research Assistant University of Dundee, College of Life Sciences Postdoctoral Fellow ? Drug Discovery / GU Oncology Moffitt Cancer Center & Research Institute More Science jobs from Drug Discovery EVENT Venomics: Drug Discovery from Nature?s Deadliest 04.11.13 New York, USA More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top

Advertisement

SciBX is pleased to present: SciBX Summit on Innovation in Drug Discovery and Development 2013 October 29-30, 2013 The Colonnade Hotel, Boston, MA, USA Click here for more information or to register for this conference today!