Scientific Reports Health Sciences Table of Contents e-alert: September 2013

02 September 2013      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports               Health Sciences               Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia ▶     Roxana Moslehi, James L. Mills, Caroline Signore et al.     We previously suggested links between specific XPD mutations in the fetal genome and the risk of placental maldevelopment and preeclampsia, possibly due to impairment of …             Sex differences in sensation-seeking: a meta-analysis ▶     Catharine P. Cross, De-Laine M. Cyrenne, Gillian R. Brown     Men score higher than women on measures of sensation-seeking, defined as a willingness to engage in novel or intense activities. This sex difference has been explained in terms of …             Digital Imprinting of RNA Recognition and Processing on a Self-Assembled Nucleic Acid Matrix ▶     Shiv K. Redhu, Matteo Castronovo, Allen W. Nicholson     The accelerating progress of research in nanomedicine and nanobiotechnology has included initiatives to develop highly-sensitive, high-throughput methods to detect biomarkers at …             A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease ▶     Penelope G. Foulds, Peter Diggle, J. Douglas Mitchell et al.     There have been no longitudinal studies on α-synuclein as a potential biomarker for the progression of Parkinson's disease (PD). Here, blood plasma ‘total α-synuclein’ and …             Daily rhythms in antennal protein and olfactory sensitivity in the malaria mosquito Anopheles gambiae ▶     Samuel S. C. Rund, Nicolle A. Bonar, Matthew M. Champion et al.     We recently characterized 24-hr daily rhythmic patterns of gene expression in Anopheles gambiae mosquitoes. These include numerous odorant binding proteins (OBPs), soluble odorant …             Expression and localization of aging markers in lacrimal gland of chronic graft-versus-host disease ▶     Masataka Kawai, Yoko Ogawa, Shigeto Shimmura et al.     Aging is commonly defined as the accumulation of diverse deleterious changes in cells and tissues with advancing age. To investigate whether aging changes are involved in the …             Diagnostic and therapeutic strategy and the most efficient prognostic factors of breast malignant fibrous histiocytoma ▶     Si-Qi Qiu, Xiao-Long Wei, Wen-He Huang et al.     We analyzed the clinicopathological features of 9 breast malignant fibrous histiocytoma (MFH) patients. Immunohistochemistry was used to make both diagnosis and differential …             Modelling dynamics of plasmid-gene mediated antimicrobial resistance in enteric bacteria using stochastic differential equations ▶     Victoriya V. Volkova, Zhao Lu, Cristina Lanzas et al.     The ubiquitous commensal bacteria harbour genes of antimicrobial resistance (AMR), often on conjugative plasmids. Antimicrobial use in food animals subjects their enteric …             Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization ▶     Huile Gao, Zhi Yang, Shuang Zhang et al.     Nanoparticles (NPs) were widely used in drugs/probes delivery for improved disease diagnosis and/or treatment. Targeted delivery to cancer cells is a highly attractive application …             Peer attachment formation by systemic redox regulation with social training after a sensitive period ▶     Mamiko Koshiba, Genta Karino, Aya Senoo et al.     Attachment formation is the most pivotal factor for humans and animals in the growth and development of social relationships. However, the developmental processes of attachment …             Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent ▶     Amaravadhi Harikishore, Makhtar Niang, Sreekanth Rajan et al.     Malaria parasite strains have emerged to tolerate the therapeutic effects of the prophylactics and drugs presently available. This resistance now poses a serious challenge to …             Direct Characterization of Bulk Samples by Internal Extractive Electrospray Ionization Mass Spectrometry ▶     Hua Zhang, Haiwei Gu, Feiyan Yan et al.     A straight-forward analytical strategy called internal extractive electrospray ionization mass spectrometry (iEESI-MS), which combines solvent extraction of chemicals inside a …             The anti-malarial chloroquine overcomes Primary resistance and restores sensitivity to Trastuzumab in HER2-positive breast cancer ▶     Sílvia Cufí, Alejandro Vazquez-Martin, Cristina Oliveras-Ferraros et al.     Autophagy may control the de novo refractoriness of HER2 gene-amplified breast carcinomas to the monoclonal antibody trastuzumab (Herceptin). Tumor cells originally obtained from …             Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo ▶     Sílvia Cufí, Rosa Bonavia, Alejandro Vazquez-Martin et al.     The flavolignan silibinin was studied for its ability to restore drug sensitivity to EGFR-mutant NSCLC xenografts with epithelial-to-mesenchymal transition (EMT)-driven resistance …             Nature of hardness evolution in nanocrystalline NiTi shape memory alloys during solid-state phase transition ▶     Abbas Amini, Chun Cheng     Due to a distinct nature of thermomechanical smart materials' reaction to applied loads, a revolutionary approach is needed to measure the hardness and to understand its size …             Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase ▶     Qing-Hua Hu, Ru-Juan Liu, Zhi-Peng Fang et al.     Streptococcus pneumoniae causes bacterial pneumonia with high mortality and morbidity. The emergency of multidrug-resistant bacteria threatens the treatment of the disease. …             No evidence for a local renin-angiotensin system in liver mitochondria ▶     Ronan Astin, Robert Bentham, Siamak Djafarzadeh et al.     The circulating, endocrine renin-angiotensin system (RAS) is important to circulatory homeostasis, while ubiquitous tissue and cellular RAS play diverse roles, including metabolic …             The Large Conductance, Calcium-activated K+ (BK) Channel is regulated by Cysteine String Protein ▶     Barry D. Kyle, Eva Ahrendt, Andrew P. Braun et al.     Large-conductance, calcium-activated-K (BK) channels are widely distributed throughout the nervous system, where they regulate action potential duration and firing frequency, …             Systemic administration of Follistatin288 increases muscle mass and reduces fat accumulation in mice ▶     Samudra S. Gangopadhyay     The present study describes the physiological response associated with daily subcutaneous injection of mice with recombinant follistatin288. This systemic administration of …             CORRIGENDUM: Estimation of autistic children by metallomics analysis ▶     Hiroshi Yasuda, Yuichi Yasuda, Toyoharu Tsutsui                 Association of telomere shortening in myocardium with heart weight gain and cause of death ▶     Masanori Terai, Naotaka Izumiyama-Shimomura, Junko Aida et al.     We attempted to clarify myocardial telomere dynamics using samples from 530 autopsied patients using Southern blot analysis. Overall regression analysis demonstrated yearly …             The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis ▶     Arasukumar Subramani, Samer Alsidawi, Sajjeev Jagannathan et al.     The brain microenvironment promotes metastasis through mechanisms that remain elusive. Co-culture of lung cancer cells with astrocytes - the most abundant cell type within the …             Aetiologies of Central Nervous System infections in adults in Kathmandu, Nepal: A prospective hospital-based study ▶     Abhishek Giri, Amit Arjyal, Samir Koirala et al.     We conducted a prospective hospital based study from February 2009-April 2011 to identify the possible pathogens of central nervous system (CNS) infections in adults admitted to a …             FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD ▶     Yusuke Fujioka, Shinsuke Ishigaki, Akio Masuda et al.     FUS is genetically and pathologically linked to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). To clarify the RNA metabolism cascade regulated …             Arginine insertion and loss of N-linked glycosylation site in HIV-1 envelope V3 region confer CXCR4-tropism ▶     Kiyoto Tsuchiya, Hirotaka Ode, Tsunefusa Hayashida et al.     The third variable region (V3) of HIV-1 envelope glycoprotein gp120 plays a key role in determination of viral coreceptor usage (tropism). However, which combinations of mutations …             The Directive 2010/63/EU on animal experimentation may skew the conclusions of pharmacological and behavioural studies ▶     Simone Macrì, Chiara Ceci, Luisa Altabella et al.     All laboratory animals shall be provided some form of environmental enrichment (EE) in the nearest future (Directive 2010/63/EU). Displacing standard housing with EE entails the …             Expanded activity of dimer nucleases by combining ZFN and TALEN for genome editing ▶     Wei Yan, Cory Smith, Linzhao Cheng     Our ability to precisely and efficiently edit mammalian and plant genomes has been significantly improved in recent years, partially due to increasing use of designer nucleases …             Cervical Cancer Screening Service Utilisation in UK ▶     Alexander Labeit, Frank Peinemann, Abbi Kedir     This study investigates empirically how past screening behaviour, individual and household characteristics affect the current uptake of cervical cancer screening in UK. For the …             Metabolic profiling of Alzheimer's disease brains ▶     Koichi Inoue, Haruhito Tsutsui, Hiroyasu Akatsu et al.     Alzheimer's disease (AD) is an irreversible, progressive brain disease and can be definitively diagnosed after death through an examination of senile plaques and neurofibrillary …             A supramolecular approach to fabricate highly emissive smart materials ▶     Kai Liu, Yuxing Yao, Yuetong Kang et al.     The aromatic chromophores, for example, perylene diimides (PDIs) are well known for their desirable absorption and emission properties. However, their stacking nature hinders the …             Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue? ▶     Lyubov V. Titova, Ayesheshim K. Ayesheshim, Andrey Golubov et al.     Terahertz (THz) radiation lies between the infrared and microwave regions of the electromagnetic spectrum and is non-ionizing. We show that exposure of artificial human skin …             Ketamine alters oscillatory coupling in the hippocampus ▶     Fábio V. Caixeta, Alianda M. Cornélio, Robson Scheffer-Teixeira et al.     Recent studies show that higher order oscillatory interactions such as cross-frequency coupling are important for brain functions that are impaired in schizophrenia, including …                     • Careers & Jobs           naturejobs.com Science jobs of the week       PhD Position     Heidelberg University, Institute of Physiology and Pathophysiology            Postdoctoral Research Assistant     University of Oxford            Postdoctoral Scientist     Medical Research Council - Laboratory of Molecular Biology            Postdoctoral Fellow     Icahn School of Medcine at Mount Sinai            Post-doctoral Researcher     The Sainsbury Laboratory (TSL)            Post-doctoral Fellow     University of Maryland, Institute for Genome Sciences            Assistant Professor of Biology     Albright College            Laboratory Technician     The Biozentrum of the University of Basel            Research Fellow     University of Texas - Medical Branch            Post-Doc Position     University of Konstanz          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. 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