Nature Reviews Molecular Cell Biology contents October 2013 Volume 14 Number 10 pp607-685

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Frontiers in Microbiology present just one of many high-quality articles:  Development of human dendritic cells and their role in HIV infection: antiviral immunity versus HIV transmission In this review, Yasuko Tsunetsugu-Yokota and Mahmod Muhsen summarize the current understanding about DC biology, antiviral immune responses and DC restriction factors, all of which will be important issues for the development of an effective AIDS vaccine in the future.
TABLE OF CONTENTS
October 2013 Volume 14 Number 10
Impact Factor 37.162 *	In this issue Research Highlights Foreword Focus on: Quality Control Reviews Also this month Article series: DNA damage  Featured article: Chaperone machines for protein folding, unfolding and disaggregation Helen Saibil
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RESEARCH HIGHLIGHTS Top Chromosomes: Architectural cohesin p607 | doi:10.1038/nrm3663 Cohesin affects interphase chromosome architecture and transcription factor positioning. PDF Protein folding: Misfolded proteins join the Q p608 | doi:10.1038/nrm3668 The identification of the 'Q body' as a dynamic quality control structure for misfolded proteins. PDF Cell signalling: Responding to intracellular pH p608 | doi:10.1038/nrm3669 Gα subunits of G protein-coupled receptors (GPCRs) transduce changes in intracellular pH to changes in GPCR signalling PDF Cell signalling: A peroxisomal home for TSC p609 | doi:10.1038/nrm3661 TSC inhibits mTORC1 in response to oxidative stress in peroxisomes. PDF Mechanotransduction: Lamin A for tension relief p610 | doi:10.1038/nrm3670 Lamin A upregulation in response to a tense extracellular environment may help to protect the nucleus. PDF Stem cells: No limits to iPS cells? p610 | doi:10.1038/nrm3671 It is possible to obtain totipotent iPS cells in vivo as well as to increase in vitro reprogramming efficiency to almost 100%. PDF JOURNAL CLUB The first chaperonin p611 | doi:10.1038/nrm3665 The first chaperonin was discovered in plants in 1980. PDF JOURNAL CLUB The many sides of CIN p611 | doi:10.1038/nrm3666 The studies that implicated CIN and aneuploidy in ageing. PDF Transcription: Proteasome power to Def1 p612 | doi:10.1038/nrm3664 Proteasomal processing of Def1 allows it to target an RNA polymerase subunit for degradation during stress. PDF IN BRIEF Protein degradation: A new player in ERAD | RNA decay: mRNAs get together | Protein stability: Getting into the membrane PDF Molecular Cell Biology JOBS of the week Postdoctoral Research Fellow (Malaria molecular biology) Nanyang Technological Univeristy, School of Biological Sciences Postdoctoral Associate @ MIT – Molecular and Synthetic Biology MIT Tenure Track Molecular Cell Biologist Emory University Department of Cell Biology Independent International Research Position in “Molecular and Cellular Basis for Tissue Homeostasis and Inflammation” IFOM (Foundation FIRC Institute of Molecular Oncology) Molecular Mechanisms and Translational Research in Kidney Cancer UT Southwestern Medical Center at Dallas, TX More Science jobs from Molecular Cell Biology EVENT Molecular Pathology and Diagnosis of Cancer 10.11.13 Cambridge, UK More science events from
FOREWORD		Top
Telling right from wrong in life — cellular quality control Georg Stoecklin & Bernd Bukau p613 | doi:10.1038/nrm3662 Abstract | Full Text | PDF
Focus on: Quality Control REVIEWS Top Protein rescue from aggregates by powerful molecular chaperone machines Shannon M. Doyle, Olivier Genest & Sue Wickner p617 | doi:10.1038/nrm3660 Disruption of the protein quality control system can lead to protein misfolding, inactivity and aggregation. New structural and biochemical insights into how disaggregases collaborate with co-chaperones and utilize ATP to untangle these aggregates are gained. This is clinically relevant as aggregation is often linked to common neurodegenerative diseases. Abstract | Full Text | PDF Chaperone machines for protein folding, unfolding and disaggregation Helen Saibil p630 | doi:10.1038/nrm3658 Chaperones are heavy-duty molecular machines that assist nascent proteins to reach their native fold but also mediate unfolding and prevent the accumulation of toxic protein aggregates. There is an increasing structural understanding of how they might perform such large-scale rearrangements. Abstract | Full Text | PDF | Supplementary information Cytoplasmic RNA: a case of the tail wagging the dog Chris J. Norbury p643 | doi:10.1038/nrm3645 The addition or removal of poly(A) tails from the 3′ ends of eukaryotic RNAs is a key regulator of RNA stability and, consequently, of gene expression. Recent work has revealed that RNA turnover is also controlled by the addition of oligo(U) tails. Abstract | Full Text | PDF PERSPECTIVES Top OPINION The RNA exosome and proteasome: common principles of degradation control Debora L. Makino, Felix Halbach & Elena Conti p654 | doi:10.1038/nrm3657 Structural and mechanistic studies have revealed common features of the way in which RNA and proteins are prepared for degradation by the exosome and proteasome, respectively. By extrapolating from what has been learnt about the proteasome, we may gain increased understanding of how its RNA counterpart, the exosome, is assembled and controlled. Abstract | Full Text | PDF
REVIEWS		Top
Article series: DNA damage Push back to respond better: regulatory inhibition of the DNA double-strand break response Stephanie Panier & Daniel Durocher p661 | doi:10.1038/nrm3659 Damage signalling in response to DNA double-strand breaks is under tight negative regulation. These control mechanisms, which include post-translational modifications and changes in chromatin structure, ensure that pathways are spatially and temporally regulated and that they become inactivated when repair is complete. Abstract | Full Text | PDF
Molecular control of the NEMO family of ubiquitin-binding proteins Kristopher Clark, Sambit Nanda & Philip Cohen p673 | doi:10.1038/nrm3644 Nuclear factor-κB (NF-κB) signalling is tightly regulated through ubiquitylation and phosphorylation of its components. Integral to this post-translational regulation is the polyubiquitin-binding protein NF-κB essential modulator (NEMO), which controls the modification of numerous NF-κB signalling proteins, such as the canonical IκB kinase (IKKs) and IKK-related kinases. Abstract | Full Text | PDF
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