Scientific Reports Health Sciences Table of Contents e-alert: August 2013

01 August 2013      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         Just one of many high quality articles Frontiers in Pediatrics has to offer: Computational fluid dynamics models and congenital heart diseases (open access) In this review article published in Frontiers in Pediatrics, Giancarlo Pennati, Francesco Migliavacca and colleagues outline recent advances in mathematical modeling in congenital heart diseases, the discoveries and limitations these models present, and future directions that are on the horizon.            Health Sciences               Nuclear MTA1 overexpression is associated with aggressive prostate cancer, recurrence and metastasis in African Americans ▶     Steven J. Dias, Xinchun Zhou, Marina Ivanovic et al.     Metastasis-associated protein 1 (MTA1), a negative epigenetic modifier, plays a critical role in prostate cancer (PCa) progression. We hypothesized that MTA1 overexpression in …             Affinity flow fractionation of cells via transient interactions with asymmetric molecular patterns ▶     Suman Bose, Rishi Singh, Mikhail Hanewich-Hollatz et al.     Flow fractionation of cells using physical fields to achieve lateral displacement finds wide applications, but its extension to surface molecule-specific separation requires …             CO2-based in-line phase contrast imaging of small intestine in mice ▶     Rongbiao Tang, Wei-Xia Li, Wei Huang et al.     The objective of this study was to explore the potential of CO2 single contrast in-line phase contrast imaging (PCI) for pre-clinical small intestine investigation. The absorption …             Human mesenchymal stem cells creating an immunosuppressive environment and promote breast cancer in mice ▶     Biljana Ljujic, Marija Milovanovic, Vladislav Volarevic et al.     Human mesenchymal stem cells (hMSC) can home to tumor sites and promote tumor growth. The effects of hMSC on tumor growth are controversial and involvement of hMSC in tumor …             Prefrontal cortical microcircuits bind perception to executive control ▶     Ioan Opris, Lucas Santos, Greg A. Gerhardt et al.     During the perception-to-action cycle, our cerebral cortex mediates the interactions between the environment and the perceptual-executive systems of the brain. At the top of the …             Novel Insights into Breast Cancer Genetic Variance through RNA Sequencing ▶     Anelia Horvath, Suresh Babu Pakala, Prakriti Mudvari et al.     Using RNA sequencing of triple-negative breast cancer (TNBC), non-TBNC and HER2-positive breast cancer sub-types, here we report novel expressed variants, allelic prevalence and …             Development and Evaluation of New Coupling System for Lower Limb Prostheses with Acoustic Alarm System ▶     Arezoo Eshraghi, Noor Azuan Abu Osman, Hossein Gholizadeh et al.     Individuals with lower limb amputation need a secure suspension system for their prosthetic devices. A new coupling system was developed that is capable of suspending the …             Spatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks ▶     Shao-Yan Sun, Zhi-Ping Liu, Tao Zeng et al.     T2DM is complex in its dynamical dependence on multiple tissues, disease states, and factors' interactions. However, most existing work devoted to characterizing its …             Polyreactive Antibodies Plus Complement Enhance the Phagocytosis of Cells Made Apoptotic by UV-Light or HIV ▶     Zhao-hua Zhou, Teresa Wild, Ying Xiong et al.     Polyreactive antibodies are a major component of the natural antibody repertoire and are capable of binding a variety of structurally unrelated antigens. Many of the properties …             GSTM1 and GSTT1 null polymorphisms and male infertility risk: an updated meta-analysis encompassing 6934 subjects ▶     Wei Wu, Jing Lu, Qiuqin Tang et al.     Published data on the association between the GST genes polymorphisms and male infertility risk are inconclusive. We investigated GST genes polymorphisms in a large sample size …             The impact of p53 in predicting clinical outcome of breast cancer patients with visceral metastasis ▶     P. Yang, C. W. Du, M. Kwan et al.     In the study, we analyzed role of p53 in predicting outcome in visceral metastasis breast cancer (VMBC) patients. 97 consecutive VMBC patients were studied. P53 positivity rate …             High arsenic in rice is associated with elevated genotoxic effects in humans ▶     Mayukh Banerjee, Nilanjana Banerjee, Pritha Bhattacharjee et al.     Arsenic in drinking water may cause major deleterious health impacts including death. Although arsenic in rice has recently been demonstrated to be a potential exposure route for …             A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds ▶     Lijin Zou, Yonglun Luo, Muwan Chen et al.     We describe a simple method for bone engineering using biodegradable scaffolds with mesenchymal stem cells derived from human induced-pluripotent stem cells (hiPS-MSCs). The …             H2O2-responsive molecularly engineered polymer nanoparticles as ischemia/reperfusion-targeted nanotherapeutic agents ▶     Dongwon Lee, Soochan Bae, Donghyun Hong et al.     The main culprit in the pathogenesis of ischemia/reperfusion (I/R) injury is the overproduction of reactive oxygen species (ROS). Hydrogen peroxide (H2O2), the most abundant form …             Nanosensor dosimetry of mouse blood proteins after exposure to ionizing radiation ▶     Dokyoon Kim, Francesco Marchetti, Zuxiong Chen et al.     Giant magnetoresistive (GMR) nanosensors provide a novel approach for measuring protein concentrations in blood for medical diagnosis. Using an in vivo mouse radiation model, we …             Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia ▶     Kun Hu, David G. Harper, Steven A. Shea et al.     Human motor activity has a robust, intrinsic fractal structure with similar patterns from minutes to hours. The fractal activity patterns appear to be physiologically important …             Memory suppression trades prolonged fear and sleep-dependent fear plasticity for the avoidance of current fear ▶     Kenichi Kuriyama, Motoyasu Honma, Takuya Yoshiike et al.     Sleep deprivation immediately following an aversive event reduces fear by preventing memory consolidation during homeostatic sleep. This suggests that acute insomnia might act …             Human mobility and the worldwide impact of intentional localized highly pathogenic virus release ▶     Bruno Gonçalves, Duygu Balcan, Alessandro Vespignani     The threat of bioterrorism and the possibility of accidental release have spawned a growth of interest in modeling the course of the release of a highly pathogenic agent. Studies …             Differential epigenome-wide DNA methylation patterns in childhood obesity-associated asthma ▶     Deepa Rastogi, Masako Suzuki, John M. Greally     While DNA methylation plays a role in T-helper (Th) cell maturation, its potential dysregulation in the non-atopic Th1-polarized systemic inflammation observed in …             S-nitrosylation regulates mitochondrial quality control via activation of parkin ▶     Kentaro Ozawa, Akira T. Komatsubara, Yuhei Nishimura et al.     Parkin, a ubiquitin E3 ligase of the ring between ring fingers family, has been implicated in mitochondrial quality control. A series of recent reports have suggested that the …             Initial Pulmonary Respiration Causes Massive Diaphragm Damage and Hyper-CKemia in Duchenne Muscular Dystrophy Dog ▶     Akinori Nakamura, Masanori Kobayashi, Mutsuki Kuraoka et al.     The molecular mechanism of muscle degeneration in a lethal muscle disorder Duchene muscular dystrophy (DMD) has not been fully elucidated. The dystrophic dog, a model of DMD, …             In Situ Breast Cancer and Microchimerism ▶     Jinny K. Eun, Katherine A. Guthrie, Gary Zirpoli et al.     Microchimeric cells of fetal origin persistent in the maternal circulation post-partum are associated with protection against invasive breast cancer. Here using quantitative …             Modeling highly pathogenic avian influenza transmission in wild birds and poultry in West Bengal, India ▶     Pranav S. Pandit, David A. Bunn, Satish A. Pande et al.     Wild birds are suspected to have played a role in highly pathogenic avian influenza (HPAI) H5N1 outbreaks in West Bengal. Cluster analysis showed that H5N1 was introduced in West …             Collagen morphology and texture analysis: from statistics to classification ▶     Leila B. Mostaço-Guidolin, Alex C.-T. Ko, Fei Wang et al.     In this study we present an image analysis methodology capable of quantifying morphological changes in tissue collagen fibril organization caused by pathological conditions. …             Specific Accumulation of Lipid Droplets in Hepatocyte Nuclei of PFOA-exposed BALB/c Mice ▶     Ling Wang, Yu Wang, Yong Liang et al.     Lipid droplets (LDs), which are important storage structures for neutral lipids and organelles of diverse functions, participate in various cellular activities. In this study, …             Global efficiency of local immunization on complex networks ▶     Laurent Hébert-Dufresne, Antoine Allard, Jean-Gabriel Young et al.     Epidemics occur in all shapes and forms: infections propagating in our sparse sexual networks, rumours and diseases spreading through our much denser social interactions, or …             Ultrasound and pH Dually Responsive Polymer Vesicles for Anticancer Drug Delivery ▶     Wenqin Chen, Jianzhong Du     Recently, smart polymer vesicles have attracted increasing interest due to their endless potential applications such as tunable delivery vehicles for the treatment of degenerative …             Pannexin 1 involvement in bladder dysfunction in a multiple sclerosis model ▶     Hiromitsu Negoro, Sarah E. Lutz, Louis S. Liou et al.     Bladder dysfunction is common in Multiple Sclerosis (MS) but little is known of its pathophysiology. We show that mice with experimental autoimmune encephalomyelitis (EAE), a MS …             Vasoconstriction by Electrical Stimulation: New Approach to Control of Non-Compressible Hemorrhage ▶     Yossi Mandel, Richard Manivanh, Roopa Dalal et al.     Non-compressible hemorrhage is the most common preventable cause of death on battlefield and in civilian traumatic injuries. We report the use of microsecond pulses of electric …             Location- and sex-specific differences in weight and motor coordination in two commonly used mouse strains ▶     Attila D. Kovács, David A. Pearce     Several studies have shown that environmental factors can affect the outcome of behavioral experiments, shedding doubts on the inter-laboratory reproducibility of behavioral test …             MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes ▶     James Kramer, Carlos A. Obejero-Paz, Glenn Myatt et al.     Drug-induced block of the cardiac hERG (human Ether-à-go-go-Related Gene) potassium channel delays cardiac repolarization and increases the risk of Torsade de Pointes (TdP), a …             Synaptic transmission and the susceptibility of HIV infection to anti-viral drugs ▶     Natalia L. Komarova, David N. Levy, Dominik Wodarz     Cell-to-cell viral transmission via virological synapses has been argued to reduce susceptibility of the virus population to anti-viral drugs through multiple infection of cells, …                 Naturejobs presents the: Naturejobs Career Expo September 19, 2013 The Business Design Centre, London, UK Click here for more information or to register for this conference today!         • Careers & Jobs           naturejobs.com Science jobs of the week       Research Technician     EMBL (European Molecular Biology Laboratory)            Postdoctoral Researcher     The Ohio State University College of Medicine            Research Associate     UCL            Junior Research / Travel Fellowships     The Kay Kendall Leukaemia Fund            Research Associate, Basic Sciences     Fred Hutchinson Cancer Research Center            Research Asst I     MD Anderson Cancer Center            Post Doctoral Research Fellow     University of Canterbury, New Zealand            Junior Research Group     University of Tübingen, Faculty of Medicine            Clinical Trials Associate     Lunenfeld - Tanenbaum Research Institute            Researcher and Instructor     Koc University School of Medicine          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. 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