Nature Review Cancer contents September 2013 Volume 13 Number 9 pp 605-678

TABLE OF CONTENTS
September 2013 Volume 13 Number 9		Advertisement
Impact Factor 35 *	In this issue Research Highlights Reviews Perspectives Also this month Article Series: Models in cancer  Featured article: Disrupting proton dynamics and energy metabolism for cancer therapy Scott K. Parks, Johanna Chiche & Jacques Pouysségur	Get the most from your NGS data with Sequenom's MassARRAY® system Validate from tens to thousands of samples across tens to hundreds of SNPs Design you own assays against any SNP of interest Run a variety of applications including genotyping, DNA methylation and somatic mutation analysis
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RESEARCH HIGHLIGHTS Top Metabolism: How sweet it is... p605 | doi:10.1038/nrc3586 Ross Cagan and colleagues have used Drosophila melanogaster to try to better understand the molecular basis for the links between type 2 diabetes and an increased risk of the development of certain types of cancer. PDF Polarity: In the plane p606 | doi:10.1038/nrc3585 This paper shows that misorientation of the spindle poles in dividing epithelial cells can lead to aberrant cell growth in the absence of apoptosis. PDF Metastasis: Active lymph nodes p606 | doi:10.1038/nrc3587 The authors identify a CCR8-CCL1 paracrine pathway that promotes the entry of melanoma cells from lymphatic vessels into the lymph node. PDF Tumour microenvironment: Means of resistance p607 | doi:10.1038/nrc3588 Resistance to therapies that target vascular endothelial growth factor may be mediated by an interleukin-17 signalling pathway in the tumour microenvironment. PDF Tumour microenvironment: Tumours have a lot of nerve p608 | doi:10.1038/nrc3583 A study reported in Science has found that sympathetic and parasympathetic nerves are involved in prostate cancer growth and dissemination in mouse models, and has begun to elucidate the molecular pathways by which nerves affect tumours, suggesting possible therapeutic approaches. PDF Therapeutics: Disrupting a survival signal p608 | doi:10.1038/nrc3584 The data in this paper indicate that the combined treatment of pancreatic ductal adenocarcinoma in mice with gemcitabine and an antibody that targets connective tissue growth factor has greater efficacy than either treatment alone owing to a reduction in the expression levels of XIAP. PDF IN BRIEF Therapeutics: Providing protection | Tumour suppressors: Nuclear PTEN | Genetics: Synonymous is not always the same | Oncogenes: Exchange needed | Therapeutics: Ubiquitylation block | Breast cancer: Giving tamoxifen a boost | Prevention: Risk prediction PDF Cancer JOBS of the week Cancer Genomics University of Southern California Bioinformatician - Centre for Lymphoid Cancer BC Cancer Agency Cancer Research Faculty Positions Tulane University Post-doc in Computational Biology & Cancer Genomics Boston University Research fellow in functional cancer genomics Memorial Sloan - Kettering Cancer Center More Science jobs from Cancer EVENT The Translational Impact of Model Organisms in Cancer 05.11.13 San Diego, USA More science events from
REVIEWS		Top
Disrupting proton dynamics and energy metabolism for cancer therapy Scott K. Parks, Johanna Chiche & Jacques Pouysségur p611 | doi:10.1038/nrc3579 Because of the increased production of acids, the altered metabolism of tumour cells renders them especially reliant on pH-regulatory systems that ensure that the intracellular pH does not decrease too much. This Review discusses the interplay among metabolism, hypoxia and pH regulation and whether pH-regulatory systems can be targeted for anticancer therapy. Abstract | Full Text | PDF
Article series: Models of cancer Zebrafish cancer: the state of the art and the path forward Richard White, Kristin Rose & Leonard Zon p624 | doi:10.1038/nrc3589 The zebrafish has emerged as an important model system with which to investigate cancer, particularly for validating genomics data and for undertaking screens for oncogenes and drivers of tumour progression and metastasis. This Review outlines what we have learned and could still learn from cancer research using the zebrafish. Abstract | Full Text | PDF
Endothelin 1 in cancer: biological implications and therapeutic opportunities Laura Rosanò, Francesca Spinella & Anna Bagnato p637 | doi:10.1038/nrc3546 Endothelin 1 (ET1) is a secreted protein that can function through autocrine and paracrine signalling to modulate various properties of cancer cells and their microenvironment. This Review describes our latest understanding of the biological roles of ET1 in cancer and the results of clinical trials with drugs that target the ET1 signalling pathway. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Fluorescence-guided surgery with live molecular navigation — a new cutting edge Quyen T. Nguyen & Roger Y. Tsien p653 | doi:10.1038/nrc3566 The efficacy of surgery is dependent on removing the entire tumour and also on not damaging important structures, such as nerves. Strategies, such as fluorescent labelling, are being developed to visually identify tumour cells and crucial structures in order to improve the safe resection of tumours. These methods have the potential to improve the survival of cancer patients, as discussed here. Abstract | Full Text | PDF
OPINION Targeting the ERBB family in cancer: couples therapy Niall Tebbutt, Mikkel W. Pedersen & Terrance G. Johns p663 | doi:10.1038/nrc3559 Many therapeutic agents target the ERBB family of receptor tyrosine kinases in various cancers. This Opinion article describes our latest understanding of the value of combining inhibitors directed towards an individual ERBB family member, including the molecular mechanisms of synergy and progress in clinical trials. Abstract | Full Text | PDF
SCIENCE AND SOCIETY Air pollution: a potentially modifiable risk factor for lung cancer Lais Fajersztajn, Mariana Veras, Ligia Vizeu Barrozo & Paulo Saldiva p674 | doi:10.1038/nrc3572 This Science and Society article addresses the possibilities of expanding scientific networking to increase awareness of the risk of lung cancer that is promoted by air pollution. Abstract | Full Text | PDF
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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