EMBO Reports - Table of Contents alert Volume 14 Issue 9, pp 749-845

TABLE OF CONTENTS September 2013 | Volume 14, Issue 9 Upfront Science & Society Scientific Reports Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Nature Medicine and Helmholtz Zentrum München present: 1st Annual Helmholtz-Nature Medicine Diabetes Conference September 22-24, 2013 Residenz München Munich, Germany  Click here for more information or to register for this conference today!   Upfront Top Editorial Yes we can, but do we? Science in Western countries is increasingly dominated by recruits from other parts of the world. Howy considers the reasons for this and whether anything could or should be done to halt this trend. Howy Jacobs EMBO reports (2013), 14, 749; 10.1038/embor.2013.123 Full text | PDF Published online: 30 August 2013 Subject Categories: Societal Issues & Politics Opinion Sirtuins and ageing—new findings Sirtuins are a promising avenue for orally administered drugs that might deliver the anti-aging benefits normally provided by calorie restriction. Leonard Guarente EMBO reports (2013), 14, 750; 10.1038/embor.2013.121 Full text | PDF Published online: 09 August 2013 Subject Categories: Cellular Metabolism Hot off the Press RNA sensing: the more RIG-I the merrier? RIG-I is an RNA helicase with important roles in immunity to RNA viruses. Two studies in this issue of EMBO reports provide new insights into the role of ATP hydrolysis by the helicase domain and RIG-I oligomerization. Jan Rehwinkel EMBO reports (2013), 14, 751 - 752; 10.1038/embor.2013.120 Full text | PDF Published online: 06 August 2013 Subject Categories: RNA | Microbiology & Pathogens Correspondence One bacterial effector with two distinct catalytic activities by different strains Christopher T D Price and Yousef Abu Kwaik EMBO reports (2013), 14, 753 - 754; 10.1038/embor.2013.126 Full text | PDF Published online: 16 August 2013 Subject Categories: Microbiology & Pathogens | Chromatin & Transcription Science & Society Top Body, heal thyself Kenneth Chien, Professor of Cardiovascular Research at Karolinska Institutet in Sweden talks about regenerative medicine and using the body's own healing potential versus stem cell-based therapies. EMBO reports (2013), 14, 755 - 758; 10.1038/embor.2013.115 Full text | PDF Published online: 13 August 2013 Subject Categories: Health & Disease The responsibility of the scientist Do scientists bear the responsibility for how their research is used? What can we learn from wartime and more recent examples of how scientists have handled dual-use problems of research? Peter Herrlich EMBO reports (2013), 14, 759 - 764; 10.1038/embor.2013.116 Full text | PDF Published online: 13 August 2013 Subject Categories: Science Policy & Funding | Philosophy & History of Science Our sense of self The genetic and molecular causes of schizophrenia have remained elusive despite intensive research. The philosophical discipline of phenomenology might now point neuroscience in a new direction. Katrin Weigmann EMBO reports (2013), 14, 765 - 768; 10.1038/embor.2013.124 Full text | PDF Published online: 13 August 2013 Subject Categories: Health & Disease A late spring in Europe and the adaptability of plants Plants seem to cope with unexpected climate conditions and retain a memory of past climates by epigenetic reprogramming. A better understanding of these mechanisms could allow breeders to create new crop varieties adapted to harsher conditions. Philip Hunter EMBO reports (2013), 14, 769 - 771; 10.1038/embor.2013.122 Full text | PDF Published online: 13 August 2013 Subject Categories: Evolution, Environment & Agriculture Scientific Reports Top Defining the functional determinants for RNA surveillance by RIG-I  EMBO Open This study shows that HEL2i-domain mediated scanning allows RIG-I to sense the length of RNA targets, and a short RNA duplex that binds one RIG-I molecule can stimulate ATPase activity and interferon response. Andrew Kohlway, Dahai Luo, David C Rawling, Steve C Ding and Anna Marie Pyle EMBO reports (2013), 14, 772 - 779; 10.1038/embor.2013.108 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 July 2013 Subject Categories: RNA | Immunology | Structural Biology ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon This study shows that RIG-I oligomerizes on Sendai virus-derived RNA in an ATP hydrolysis and dsRNA length dependent manner. Oligomerization correlates with the strength of interferon activation, thus identifying the role of the elusive RIG-I ATPase activity. Jenish R Patel, Ankur Jain, Yi-ying Chou, Alina Baum, Taekjip Ha and Adolfo García-Sastre EMBO reports (2013), 14, 780 - 787; 10.1038/embor.2013.102 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 July 2013 Subject Categories: Immunology | Microbiology & Pathogens | RNA Casein kinase 2 is essential for mitophagy Atg32 is the yeast mitophagy receptor for mitophagy, a process that selectively degrades mitochondria. Here, CK2 is shown to phosphorylate Atg32 and be essential for Atg32-Atg11 interaction and ensuing mitophagy. Tomotake Kanki, Yusuke Kurihara, Xiulian Jin, Tadahiro Goda, Yusuke Ono, Masamune Aihara, Yuko Hirota, Tetsu Saigusa, Yoshimasa Aoki, Takeshi Uchiumi and Dongchon Kang EMBO reports (2013), 14, 788 - 794; 10.1038/embor.2013.114 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 July 2013 Subject Categories: Signal Transduction | Proteins Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development  EMBO Open Atg7 deletion in Myf5+ progenitors blocks autophagy in brown adipose tissue and muscle, affecting their differentiation and function. Knockout mice have higher body temperatures and glucose intolerance, underscoring the importance of autophagy in these processes. Nuria Martinez-Lopez, Diana Athonvarangkul, Srabani Sahu, Luisa Coletto, Haihong Zong, Claire C Bastie, Jeffrey E Pessin, Gary J Schwartz and Rajat Singh EMBO reports (2013), 14, 795 - 803; 10.1038/embor.2013.111 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 02 August 2013 Subject Categories: Cellular Metabolism | Development Structural insights into substrate recognition in proton-dependent oligopeptide transporters The structure of the bacterial proton dependent oligopeptide transporter PepTSo2 is presented in the inward open conformation in complex with the peptidomimetic alafosfalin. The ligand binding sites defined by this study are highly conserved and the structural insights presented here are therefore likely to also apply to human POTs. Fatma Guettou, Esben M Quistgaard, Lionel Trésaugues, Per Moberg, Caroline Jegerschöld, Lin Zhu, Agnes Jin Oi Jong, Pär Nordlund and Christian Löw EMBO reports (2013), 14, 804 - 810; 10.1038/embor.2013.107 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 19 July 2013 Subject Categories: Membranes & Transport | Structural Biology The ribosome triggers the stringent response by RelA via a highly distorted tRNA The bacterial stringent response is initiated by RelA and links nutrient starvation with the transcriptional control of genes. Cryo-EM now shows that RelA on the ribosome stabilizes an unusual distorted form of cognate, deacylated tRNA. Xabier Agirrezabala, Israel S Fernández, Ann C Kelley, David Gil Cartón, Venki Ramakrishnan and Mikel Valle EMBO reports (2013), 14, 811 - 816; 10.1038/embor.2013.106 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 July 2013 Subject Categories: Structural Biology | RNA | Proteins ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis In plants, SOG1 regulates transcription, cell cycle arrest and cell death in response to DNA damage. This study reports that ATM-mediated phosphorylation of SOG1 is essential for this response. As SOG1 and p53 have no sequence similarity, they are likely an example of convergent evolution. Kaoru O Yoshiyama, Junya Kobayashi, Nobuo Ogita, Minako Ueda, Seisuke Kimura, Hisaji Maki and Masaaki Umeda EMBO reports (2013), 14, 817 - 822; 10.1038/embor.2013.112 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 02 August 2013 Subject Categories: Genome Stability & Dynamics | Plant Biology Parent-of-origin control of transgenerational retrotransposon proliferation in Arabidopsis The authors of this study observe parent-of-origin effects regulating retrotransposition in Arabidopsis characterized by expansion and suppression in the paternal and maternal germ line, respectively. The parent-of-origin effect was still observed when gametophytes carried mutations for key epigenetic regulators indicating that the suppressive regulation occurs in the maternal sporophytic tissues. Jon Reinders, Marie Mirouze, Joël Nicolet and Jerzy Paszkowski EMBO reports (2013), 14, 823 - 828; 10.1038/embor.2013.95 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 09 July 2013 Subject Categories: Genome Stability & Dynamics | Plant Biology Aurora A kinase and its substrate TACC3 are required for central spindle assembly This study shows that Aurora A-in addition to its role metaphase bipolar spindle assembly-is required for the generation of a robust anaphase central spindle. Aurora A substrate TACC3 participates in this process. Antonios Lioutas and Isabelle Vernos EMBO reports (2013), 14, 829 - 836; 10.1038/embor.2013.109 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 26 July 2013 Subject Categories: Cell Cycle | Cell & Tissue Architecture Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling The protein kinase ILK promotes the movement of Smoothened into the mouse primary cilium and is required for the induction of Gli transcription factors in response to Sonic Hedgehog. Badia Barakat, Liang Yu, Camden Lo, Duc Vu, Elisabetta De Luca, Jason E Cain, Luciano G Martellotto, Shoukat Dedhar, Anthony J Sadler, Die Wang, D Neil Watkins and Gregory E Hannigan EMBO reports (2013), 14, 837 - 844; 10.1038/embor.2013.110 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 July 2013 Subject Categories: Signal Transduction Corrections Top Corrigendum The puzzle of TRPV4 channelopathies Bernd Nilius and Thomas Voets EMBO reports (2013), 14, 845; 10.1038/embor.2013.134 Full text | PDF Published online: 20 August 2013 Corrigenda The chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres Anna Postepska-Igielska, Damir Krunic, Nina Schmitt, Karin M Greulich-Bode, Petra Boukamp and Ingrid Grummt EMBO reports (2013), 14, 845; 10.1038/embor.2013.135 Full text | PDF Published online: 20 August 2013 Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling Ekatherina Serysheva, Hebist Berhane, Luca Grumolato, Kubilay Demir, Sophie Balmer, Maxime Bodak, Michael Boutros, Stuart Aaronson, Marek Mlodzik and Andreas Jenny EMBO reports (2013), 14, 845; 10.1038/embor.2013.136 Full text | PDF Published online: 20 August 2013 Advertisement Top Downloads in 2013 The multifaceted role of mTORC1 in the control of lipid metabolism  Stéphane Ricoult & Brendan Manning   Mechanosensitivity and compositional dynamics of cell-matrix adhesions Herbert Schiller & Reinhard Fässler    Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. 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