| [Rethink how outputs of scientific research are evaluated] New from eLife July 9, 2013 Research Articles Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells The quantitative details of single molecule pMHC:T-cell receptor unbinding kinetics, stoichiometry, and signaling molecule recruitment have been measured in living primary T cells, providing insights into TCR triggering mechanisms. Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues Nutrient limitation elicits differential responses in cells lacking the tumor suppressor PTEN and in normal cells, resulting in hyperplastic overgrowth of PTEN mutant tissue independent of additional mutations. Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis C-terminal phosphorylation of the lipid phosphatase PTEN drives a reduction in membrane affinity and leads to a more compact conformation that involves a C2 domain-tail interaction. Apical targeting of the formin Diaphanous in Drosophila tubular epithelia Synergistic interactions with PI(4,5)P2 and activated Rho1, which are enriched at the apical membrane of tubular organs, facilitate tight apical targeting of the formin Diaphanous. TRiC’s tricks inhibit huntingtin aggregation Cryo-electron tomography reveals how a chaperone protein called TRiC reduces the ability of pathogenic mutant huntingtin proteins to form aggregates. Hypothemicin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei Hypothemycin, which inhibits a number of protein kinases, kills the T. brucei parasites that cause sleeping sickness and reveals new therapeutic targets for the disorder. Skill learning strengthens cortical representations of motor sequences Detailed analysis of fMRI data shows that sequences of movements are associated with individual patterns of neural activity that become more distinct with training. Insights Chemical biology: Closing in on a new treatment for sleeping sickness _________________________________________________________________________________ For the media Your contact is Jennifer McLennan: j.mclennan@elifesciences.org, +1-202-631-8854. Please cite eLife as the source of these articles and include a link to either the article or elifesciences.org. Thank you! More details available at http://www.elifesciences.org/news/for-the-press. To be notified of new content at eLife, sign up at http://www.elifesciences.org/crm/civicrm/profile/create?reset=1&gid=11. ________________ eLife is accepting submissions. Learn more and submit your best work at submit.elifesciences.org. ________________ Thanks for subscribing to receive updates from eLife, the new journal for the very best in life science and biomedical research, supported by the Howard Hughes Medical Institute, the Max Planck Society, and the Wellcome Trust. If you have any questions or comments, feel free to contact us at http://www.elifesciences.org/contact. More information about eLife is available at http://www.elifesciences.org. Did you receive this email as a forward? Make sure to receive all our updates by subscribing now at http://www.elifesciences.org/crm/civicrm/profile/create?reset=1&gid=11.
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