Monday, 1 July 2013

EMBO Reports - Table of Contents alert Volume 14 Issue 7 pp 577-658


TABLE OF CONTENTS
June 2013 | Volume 14, Issue 7
Upfront
Science & Society
Review
Scientific Reports

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Upfront

Top

Editorial

1914–2014: never again

The coming year marks the centenary of the events that lead to the global catastrophe of July 1914. Howy appeals for a worldwide movement to prevent any possibility of such a disaster occurring in today's equally unstable world.
Howy Jacobs
EMBO reports (2013), 14, 577; 10.1038/embor.2013.78
Published online: 01 July 2013
Subject Categories: Societal Issues & Politics

Opinion

The right to care and the expectations of society—controversial stem cell therapy in Italy

Claiming that a disease is incurable does not justify the use of unsafe or ineffective therapies. Instead, the process of drug approval as a whole should be improved, with all involved giving clear and honest answers to ensure the dignity of patients and quality of care.
Maurizio Bifulco and Patrizia Gazzerro
EMBO reports (2013), 14, 578; 10.1038/embor.2013.71
Published online: 04 June 2013

Hot off the Press

A dual role of SNAP-25 as carrier and guardian of synaptic transmission

In this issue, Matteoli and colleagues show that SNAP-25 levels regulate the efficacy of presynaptic glutamate release and thereby alter short-term plasticity, with potential relevance for psychiatric diseases.
Gaga Kochlamazashvili and Volker Haucke
EMBO reports (2013), 14, 579 - 580; 10.1038/embor.2013.74
Published online: 04 June 2013
Subject Categories: Neuroscience

Feed backwards model for microRNA processing and splicing in plants

Two studies in this issue of EMBO reports show that 3′ adjacent introns of plant miRNAs enhance miRNA biogenesis and that miRNA processing inhibits 3′ intron splicing.
Ashish Dhir and Nick J Proudfoot
EMBO reports (2013), 14, 581 - 582; 10.1038/embor.2013.77
Published online: 14 June 2013
Subject Categories: RNA

Rejuvenating Tithonus

Four recent publications, including one in this issue by Surani and colleagues, report that Prdm14 preserves the pluripotent stem cell state by inhibiting FGF signalling and global DNA methylation.
Kyle M Loh and Bing Lim
EMBO reports (2013), 14, 583 - 584; 10.1038/embor.2013.81
Published online: 14 June 2013
Subject Categories: Chromatin & Transcription | Development

Meeting Point

Seaside transportation—from structure to function of translocation machines

The EMBO conference, ‘From Structure to Function of Translocation Machines’, took place in April 2013 in Dubrovnik, Croatia. The meeting brought together a mix of established and aspiring researchers to discuss a wealth of unpublished data and ideas in a lively scientific program of talks designed to shatter the established dogma.
Trevor Lithgow and Gabriel Waksman
EMBO reports (2013), 14, 585 - 587; 10.1038/embor.2013.79
Published online: 14 June 2013

Science & Society

Top

Sex determination

How the sex of offspring is determined has puzzled philosophers and scientists for millennia. Modern science has identified both genetic and environmental factors, but the question is still not yet fully answered.
Ursula Mittwoch
EMBO reports (2013), 14, 588 - 592; 10.1038/embor.2013.84
Published online: 14 June 2013

Inheritance of poor writing habits

More than a century spent lamenting the terrible habits and conceits of scientific writing has done little to improve things. A sea change is going to require the concerted efforts of all those involved in writing up and publishing research.
Amin Bredan
EMBO reports (2013), 14, 593 - 596; 10.1038/embor.2013.76
Published online: 04 June 2013

Elixirs of death

Substandard and fake drugs are increasingly threatening lives in both the developed and developing world, but governments and industry are struggling to improve the situation.
Katrin Weigmann
EMBO reports (2013), 14, 597 - 600; 10.1038/embor.2013.82
Published online: 14 June 2013

The science of progress and the progress of science

Measuring the true impact of science is a Herculean task. Meta-science studies are beginning to assess more than just publication metrics to gain a fuller, long-term view of the value of research.
Philip Hunter
EMBO reports (2013), 14, 601 - 604; 10.1038/embor.2013.83
Published online: 14 June 2013

Review

Top

The DLK signalling pathway—a double-edged sword in neural development and regeneration

This review discusses the multifaceted roles of DLK, a MAPKKK, signalling pathways in neural development and degeneration as well as axon regeneration after injury in diverse model organisms. The authors also outline strategies for how DLK function might be combined with other approaches to promote mammalian axon regeneration.
Andrea Tedeschi and Frank Bradke
EMBO reports (2013), 14, 605 - 614; 10.1038/embor.2013.64
Published online: 17 May 2013
Subject Categories: Neuroscience | Signal Transduction

Scientific Reports

Top

Enhanced microRNA accumulation through stemloop-adjacent introns

This study reveals tight interactions between intron splicing and miRNA processing in plants: introns proximal to plant miRNA stem-loops promote miRNA maturation in a splicing-independent manner, whereas reduced miRNA processing enhances splicing of such miRNA-proximal introns.
Rebecca Schwab, Corinna Speth, Sascha Laubinger and Olivier Voinnet
EMBO reports (2013), 14, 615 - 621; 10.1038/embor.2013.58
Published online: 10 May 2013
Subject Categories: RNA | Plant Biology

Introns of plant pri-miRNAs enhance miRNA biogenesis  EMBO Open

miRNA-proximal introns and functional splice sites are required for the accumulation of normal levels and the activity of mature miRNAs in Arabidopsis.
Dawid Bielewicz, Malgorzata Kalak, Maria Kalyna, David Windels, Andrea Barta, Franck Vazquez, Zofia Szweykowska-Kulinska and Artur Jarmolowski
EMBO reports (2013), 14, 622 - 628; 10.1038/embor.2013.62
Published online: 17 May 2013
Subject Categories: RNA

Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation  EMBO Open

The transcription factor Prdm14 is a critical regulator of pluripotency and germline development. This study shows that Prdm14 represses DNA methylation and FGF signaling, thereby promoting both germ cell fate and naive pluripotency in ESC.
Nils Grabole, Julia Tischler, Jamie A Hackett, Shinseog Kim, Fuchou Tang, Harry G Leitch, Erna Magnúsdóttir and M Azim Surani
EMBO reports (2013), 14, 629 - 637; 10.1038/embor.2013.67
Published online: 14 May 2013

Degradation of IF1 controls energy metabolism during osteogenic differentiation of stem cells

The ATPase inhibitory factor 1 (IF1) is a stem cell marker that regulates energy metabolism of human mesenchymal stem cells (hMSCs). The regulated degradation of IF1 hinders self-renewal of stem cells to favour differentiation.
María Sánchez-Aragó, Javier García-Bermúdez, Inmaculada Martínez-Reyes, Fulvio Santacatterina and José M Cuezva
EMBO reports (2013), 14, 638 - 644; 10.1038/embor.2013.72
Published online: 31 May 2013

Reduced SNAP-25 alters short-term plasticity at developing glutamatergic synapses

SNAP-25, a key component of the synapse, is reduced in brain areas of schizophrenic patients. This study shows that SNAP-25 levels alter short-term plasticity, which might contribute to neural alterations in psychiatric diseases.
Flavia Antonucci, Irene Corradini, Raffaella Morini, Giuliana Fossati, Elisabetta Menna, Davide Pozzi, Simone Pacioni, Claudia Verderio, Alberto Bacci and Michela Matteoli
EMBO reports (2013), 14, 645 - 651; 10.1038/embor.2013.75
Published online: 04 June 2013
Subject Categories: Structural Biology

Arabidopsis ARGONAUTE7 selects miR390 through multiple checkpoints during RISC assembly

Plant AGO7 assembles RISC specifically with miR390 and regulates the auxin signalling pathway. This study shows that AGO7 uses multiple checkpoints and a unique passenger ejection mechanism to select miR390.
Yayoi Endo, Hiro-oki Iwakawa and Yukihide Tomari
EMBO reports (2013), 14, 652 - 658; 10.1038/embor.2013.73
Published online: 04 June 2013
Subject Categories: RNA | Plant Biology | Proteins
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