Next Generation Sequencing Newsletter July 2013

Next Generation Sequencing Newsletter

July 2013

NextGenSeq@nature.com provides a feel for the current state of the art in next generation sequencing technologies and how these platforms are changing the face of biomedical research. The page hosts a collection of original research, commentary and reviews published by Nature Publishing Group. Sign up for monthly e-alerts from Next Generation Sequencing.

Highlighted articles Access these articles for FREE by visiting NextGenSeq@nature.com   A largely random AAV integration profile after LPLD gene therapy FREE Christine Kaeppel, Stuart G Beattie, Raffaele Fronza, Richard van Logtenstein, Florence Salmon, Sabine Schmidt, Stephan Wolf, Ali Nowrouzi, Hanno Glimm, Christof von Kalle, Harald Petry, Daniel Gaudet & Manfred Schmidt Nature Medicine doi:10.1038/nm.3230   Uniform, optimal signal processing of mapped deep-sequencing data FREE Vibhor Kumar, Masafumi Muratani, Nirmala Arul Rayan, Petra Kraus, Thomas Lufkin, Huck Hui Ng & Shyam Prabhakar Nature Biotechnology doi:10.1038/nbt.2596   Next-generation carrier screening FREE Mark A. Umbarger, Caleb J. Kennedy, Patrick Saunders, Benjamin Breton, Niru Chennagiri, John Emhoff, Valerie Greger, Stephanie Hallam, David Maganzini, Cynthia Micale, Marcia M. Nizzari, Charles F. Towne, George M. Church & Gregory J. Porreca Genetics in Medicine doi:10.1038/gim.2013.83   Targeted next-generation sequencing as a comprehensive test for patients with and female carriers of DMD/BMD: a multi-population diagnostic study FREE Xiaoming Wei, Yi Dai, Ping Yu, Ning Qu, Zhangzhang Lan, Xiafei Hong, Yan Sun, Guanghui Yang, Shuqi Xie, Quan Shi, Hanlin Zhou, Qian Zhu, Yuxing Chu, Fengxia Yao, Jinming Wang, Jingni He, Yun Yang, Yu Liang, Yi Yang, Ming Qi, Ling Yang, Wei Wang, Haitao Wu, Jing Duan, Cheng Shen, Jun Wang, Liying Cui & Xin Yi European Journal of Human Genetics doi:10.1038/ejhg.2013.82 NPG journal-based collections of interest   Applications of next–generation sequencing (Series in Nature Reviews Genetics)   Focus on Next-Generation Sequencing (Supplement from Nature Biotechnology) Recent articles from NPG Access these articles by visiting NextGenSeq@nature.com   Exome sequencing as a diagnostic tool to identify a causal mutation in genetically highly heterogeneous limb-girdle muscular dystrophy Tohru Matsuura, Tatsuaki Kurosaki, Yoshio Omote, Narihiro Minami, Yukiko K Hayashi, Ichizo Nishino & Koji Abe Journal of Human Genetics doi:10.1038/jhg.2013.33   The use of next-generation sequencing in clinical diagnosis of familial hypercholesterolemia Jana Vandrovcova, Ellen R.A. Thomas, Santosh S Atanur, Penny J. Norsworthy, Clare Neuwirth, Yvonne Tan, Dalia Kasperaviciute, Jennifer Biggs, Laurence Game, Michael Mueller, Anne K. Soutar & Timothy J. Aitman Genetics in Medicine doi:10.1038/gim.2013.55   Comparative analysis of RNA sequencing methods for degraded or low-input samples Xian Adiconis, Diego Borges-Rivera, Rahul Satija, David S DeLuca, Michele A Busby, Aaron M Berlin, Andrey Sivachenko, Dawn Anne Thompson, Alec Wysoker, Timothy Fennell, Andreas Gnirke, Nathalie Pochet, Aviv Regev & Joshua Z Levin Nature Methods doi:10.1038/nmeth.2483   Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles Melissa K McConechy, Jiarui Ding, Janine Senz, Winnie Yang, Nataliya Melnyk, Alicia A Tone, Leah M Prentice, Kimberly C Wiegand, Jessica N McAlpine, Sohrab P Shah, Cheng-Han Lee, Paul J Goodfellow, C Blake Gilks & David G Huntsman Modern Pathology doi:10.1038/modpathol.2013.107   Genome-wide measurement of protein-DNA binding dynamics using competition ChIP Colin R Lickwar, Florian Mueller & Jason D Lieb Nature Protocols doi:10.1038/nprot.2013.077   The Macrophage: A New Factor in UVR-Induced Melanomagenesis Tao Wang & Meenhard Herlyn Journal of Investigative Dermatology doi:10.1038/jid.2013.93