The EMBO Journal - Table of Contents alert Volume 32 Issue 17

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Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement EMBO Transparent Process  TRANSPARENT - Referee reports published (without attribution) - No confidential comments   FAIR - Referee cross-commenting for balanced decisions - Scooping protection during review and revision FAST <1 week to a first decision and <1 month to complete peer-review >90% of published manuscripts undergo a single round of revision (taking on average 3 months) >95% invited revisions are published Have you seen? Top Histone deacetylases govern heterochromatin in every phase Sir2-dependent histone deacetylation recruits the histone methyltransferase Clr4, spreading repressive H3K9-methylation during centromeric heterochromatin assembly. Yota Murakami The EMBO Journal (2013), 32, 2301 - 2303; 10.1038/emboj.2013.154 Abstract | Full text | PDF | Related article Published online: 05 July 2013 Twisting chromatin in stem cells Assessment of the higher-order genome structure in various types of pluripotent stem cells revealed a rather unique genomic landscape/pattern of chromatin organization, predominantly governed by the pluripotency transcription factor network. Paul Ginno and Dirk Schübeler The EMBO Journal (2013), 32, 2304 - 2306; 10.1038/emboj.2013.179 Abstract | Full text | PDF | Related article Published online: 06 August 2013 Review Top The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications Pascal Genschik and colleagues review the fascinating array of signalling, cell cycle, and stress response roles that Cullin3/Rbx1/BTB-protein ubiquitin ligases play in both metazoan organisms and higher plants. Pascal Genschik, Izabela Sumara and Esther Lechner The EMBO Journal (2013), 32, 2307 - 2320; 10.1038/emboj.2013.173 Abstract | Full text | PDF Published online: 02 August 2013 Articles Top Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast  EMBO Open The demonstration that H3K14 deacetylation promotes recruitment of the Clr4 histone methyltransferase establishes a new function for the Sir2 deacetylase in de novo heterochromatin formation. Benjamin J Alper, Godwin Job, Rajesh K Yadav, Sreenath Shanker, Brandon R Lowe and Janet F Partridge The EMBO Journal (2013), 32, 2321 - 2335; 10.1038/emboj.2013.143 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 June 2013 Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury Lysosomal damage can lead to oxidative stress, inflammation, and apoptosis or necrosis. Damaged lysosomes recruit the autophagic machinery leading to their sequestration. Loss of autophagy increases the kidney damage resulting from lysosomal damage. Ikuko Maejima, Atsushi Takahashi, Hiroko Omori, Tomonori Kimura, Yoshitsugu Takabatake, Tatsuya Saitoh, Akitsugu Yamamoto, Maho Hamasaki, Takeshi Noda, Yoshitaka Isaka and Tamotsu Yoshimori The EMBO Journal (2013), 32, 2336 - 2347; 10.1038/emboj.2013.171 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 August 2013 Mfn2 modulates the UPR and mitochondrial function via repression of PERK Mitochondrial–ER bridging protein mitofusin 2 (Mfn2) orchestrates mitochondrial metabolism and the UPR by suppressing PERK. Juan Pablo Muñoz, Saška Ivanova, Jana Sánchez-Wandelmer, Paula Martínez-Cristóbal, Eduard Noguera, Ana Sancho, Angels Díaz-Ramos, María Isabel Hernández-Alvarez, David Sebastián, Caroline Mauvezin, Manuel Palacín and Antonio Zorzano The EMBO Journal (2013), 32, 2348 - 2361; 10.1038/emboj.2013.168 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 August 2013 The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit The ubiquitous mitochondrial calcium uniporter (MCU) oligomerizes to form pores. MCU also oligomerizes with a new dominant-negative isoform, MCUb, which blocks calcium uptake revealing a new mechanism of mitochondrial calcium homeostasis and thus aerobic metabolism and apoptosis. Anna Raffaello, Diego De Stefani, Davide Sabbadin, Enrico Teardo, Giulia Merli, Anne Picard, Vanessa Checchetto, Stefano Moro, Ildikò Szabò and Rosario Rizzuto The EMBO Journal (2013), 32, 2362 - 2376; 10.1038/emboj.2013.157 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 July 2013 MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways B cell-specific knockout of the miRNA 17~92 cluster corroborates its oncogenic properties. Application of PAR-CLIP establishes unique and novel molecular targets of this first-ever described oncogenic miRNA Hyun Yong Jin, Hiroyo Oda, Maoyi Lai, Rebecca L Skalsky, Kelly Bethel, Jovan Shepherd, Seung Goo Kang, Wen-Hsien Liu, Mohsen Sabouri-Ghomi, Bryan R Cullen, Klaus Rajewsky and Changchun Xiao The EMBO Journal (2013), 32, 2377 - 2391; 10.1038/emboj.2013.178 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 August 2013 WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition The methyltransferase WHSC1 contributes to P-TEFb-dependent transcriptional elongation and drives prolonged incorporation of the histone variant H3.3 into inducible genes. Naoyuki Sarai, Keisuke Nimura, Tomohiko Tamura, Tomohiko Kanno, Mira C Patel, Tom D Heightman, Kiyoe Ura and Keiko Ozato The EMBO Journal (2013), 32, 2392 - 2406; 10.1038/emboj.2013.176 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 August 2013 Mobilization of a plant transposon by expression of the transposon-encoded anti-silencing factor In Arabidopsis, the autonomously mobile element Hiun counteracts DNA methylation-induced silencing by expression of an anti-silencer protein—a mechanism that might have led to its broad distribution in plants. Yu Fu, Akira Kawabe, Mathilde Etcheverry, Tasuku Ito, Atsushi Toyoda, Asao Fujiyama, Vincent Colot, Yoshiaki Tarutani and Tetsuji Kakutani The EMBO Journal (2013), 32, 2407 - 2417; 10.1038/emboj.2013.169 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 July 2013 Erratum Top Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst Rita O Teodoro, Gulçin Pekkurnaz, Abdullah Nasser, Misao E Higashi-Kovtun, Maria Balakireva, Ian G McLachlan, Jacques Camonis and Thomas L Schwarz The EMBO Journal (2013), 32, 2418 - 2419; 10.1038/emboj.2013.181 Full text | PDF Published online: 28 August 2013 Advertisement Take part in our reader survey for a chance to win a MacBook Air As a reader of NPG's clinical and society-owned journals, we invite you to take part in a survey on your use of our journals and their associated websites. Take the survey and be entered into a prize draw for a MacBook Air* *Terms & conditions apply   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. 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