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| TABLE OF CONTENTS | |||||||||||||||||||||||||||||||||||||
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| September 2013 Volume 9 Number 9 | |||||||||||||||||||||||||||||||||||||
| In this issue  Research HighlightsNews and ViewsCorrectionReviewsCorrespondence
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| NEWS AND VIEWS | Top | ||||||||||||||||||||||||||||||||||||
| Thrombotic microangiopathy: Eculizumab for atypical haemolytic uraemic syndrome: what next? Fadi Fakhouri & Véronique Frémeaux-Bacchi Published online: 06 August 2013 p495 | doi:10.1038/nrneph.2013.150 Effective treatments for atypical haemolytic uraemic syndrome (aHUS) have long been lacking, but the discovery that complement dysregulation is a major risk factor for this disease and the availability of the complement inhibitor eculizumab have improved the clinical picture. Legendre et al. have now published results from two prospective trials investigating eculizumab use in aHUS. Although we have come a long way, questions remain. Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| Chronic kidney disease: Epic battles in the phosphate-binder wars—the last episode? Adrian Covic & Luminita Voroneanu Published online: 30 July 2013 p497 | doi:10.1038/nrneph.2013.149 Whether use of non-calcium-containing phosphate binders versus calcium-containing phosphate binders improves outcomes for patients with chronic kidney disease is unclear. Now, new data from an open-label randomized controlled trial suggest that the non-calcium-containing phosphate binder sevelamer hydrochloride significantly improves survival compared to calcium carbonate in incident patients on haemodialysis. Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| Haemodialysis: Prediction of brachial artery blood flow for fistula creation Miguel C. Riella & Arif Asif Published online: 06 August 2013 p498 | doi:10.1038/nrneph.2013.151 Caroli et al. recently used a haemodynamic computational model to simulate changes in vessel dimensions and blood flow volumes in response to arteriovenous fistula (AVF) creation. This study has provided new insights into the use of preoperative ultrasound to identify sites for AVF creation and reduce rates of fistula nonmaturation. Full Text | PDF | |||||||||||||||||||||||||||||||||||||
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| CORRECTION | Top | ||||||||||||||||||||||||||||||||||||
| Resistant hypertension—its identification and epidemiology Pantelis A. Sarafidis, Panagiotis Georgianos & George L. Bakris Published online: 09 July 2013 p492 | doi:10.1038/nrneph.2013.148 Full Text | PDF | |||||||||||||||||||||||||||||||||||||
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| REVIEWS | Top | ||||||||||||||||||||||||||||||||||||
| The primary glomerulonephritides: a systems biology approach Song Jiang, Peter Y. Chuang, Zhi-Hong Liu & John C. He Published online: 16 July 2013 p500 | doi:10.1038/nrneph.2013.129 The integration of omics analyses of primary glomerular diseases with data from clinical and histopathological studies is expected to advance our understanding of the molecular basis of these diseases and lead to improvements in diagnosis and treatment. Here, the authors provide an up-to-date overview of omics studies of primary glomerular diseases and suggest new approaches to further characterize their pathogenetic mechanisms, candidate genes, potential biomarkers and therapeutic targets. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| The applicability of eGFR equations to different populations Pierre Delanaye & Christophe Mariat Published online: 16 July 2013 p513 | doi:10.1038/nrneph.2013.143 Various equations have been developed for estimating glomerular filtration rate (GFR), but the issues surrounding GFR estimation are heavily debated. Although many guidelines now recommend the newer MDRD and CKD-EPI equations over the Cockcroft-Gault equation, these equations do fail to provide accurate estimates of GFR in some situations. This article discusses the development of the different equations and describes clinical situations in which the applicability of the equations is questioned. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| Nephrology in China Zhi-Hong Liu Published online: 23 July 2013 p523 | doi:10.1038/nrneph.2013.146 In this Review, Zhi-Hong Liu describes the current status of nephrology in China, with particular reference to chronic kidney disease, acute kidney injury and kidney transplantation. She also discusses the potential of Chinese health-care reforms to increase the prevalence of dialysis and improve long-term outcomes for patients with chronic kidney disease. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| Renal cancer in von Hippel–Lindau disease and related syndromes Birke Bausch, Cordula Jilg, Sven Gläsker, Alexander Vortmeyer, Niklas Lützen, Alexandra Anton,Charis Eng & Hartmut P. H. Neumann Published online: 30 July 2013 p529 | doi:10.1038/nrneph.2013.144 Sporadic and hereditary forms of renal cell carcinoma, von Hippel–Lindau (VHL) disease and the familial paraganglioma syndromes are closely related in terms of their clinical and molecular genetic aspects. In this Review, the authors discuss pathogenesis, treatment and preventive strategies for VHL disease, VHL-disease-specific renal lesions, and familial paraganglioma syndromes. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
| Obesity-related cardiorenal disease: the benefits of bariatric surgery Wiebke Fenske, Thanos Athanasiou, Leanne Harling, Christiane Drechsler, Ara Darzi & Hutan Ashrafian Published online: 06 August 2013 p539 | doi:10.1038/nrneph.2013.145 Obesity-related metabolic syndrome is a growing health concern. The heart and kidneys are physiologically interdependent, and the pathological effects of obesity can lead to cardiorenal syndrome and, ultimately, kidney and heart failure. In this Review, the authors describe the complex interactions by which obesity might affect physiological cardiorenal interactions. They also discuss the potential roles of surgically induced weight loss and enhanced metabolic activity in the treatment of obesity-related cardiorenal syndrome. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
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| CORRESPONDENCE | Top | ||||||||||||||||||||||||||||||||||||
| Effect of rituximab in MCNS: a role for IL-13 suppression? Ji Eun Kim, Se Jin Park, Tae-Sun Ha & Jae Il Shin Published online: 30 July 2013 p551 | doi:10.1038/nrneph.2012.289-c1 Full Text | PDF | |||||||||||||||||||||||||||||||||||||
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| *Journal Citation Reports, Thomson, 2012. Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology. |
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