Nature Reviews Genetics Contents 2013 Volume 14 Number 9 pp 595 - 673

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TABLE OF CONTENTS
September 2013 Volume 14 Number 9		Advertisement
Impact Factor 41.063 *	In this issue Research Highlights Progress Reviews Analysis Also this month Article series: Applications of next-generation sequencing Disease mechanisms  Featured article: Single-cell sequencing-based technologies will revolutionize whole-organism science Ehud Shapiro, Tamir Biezuner & Sten Linnarsson	Circulation: Cardiovascular Genetics is the top journal dedicated to in cardiovascular genetics, genomics, and systems biology. See for yourself - all content older than 12 months and Editor's Picks articles published with each issue are freely accessible on Circulation: Cardiovascular Genetics' Web site.
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Genetics Society - From Genes to Shape Registration is now OPEN:Early Registration deadline: 07.10.13 | Abstract submission deadline: 05.09.13 Organizers — Enrico Coen, Buzz Baum  Speakers — Andreas Bausch, Anja Geitmann, Benedicte Sanson Francois Nedelec, Frank Julicher, James Sharpe Jan Traas, Jeremy Green, Max Heiman Raymond Goldstein, Sophie Martin, Stanislas Leibler Veronica Grieneisen http://www.genetics.org.uk/Conferences/tabid/84/MeetingNo/ GTS_AM2013/view/Conference/Default.aspx
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At the intersection of non-coding transcription, DNA repair, chromatin structure, and cellular senescence (open access) In this review article published in Frontiers in Genetics, Ryosuke Ohsawa, Ja-Hwan Seol and Jessica K. Tyler discuss how the fine balance between transcription and genomic instability may be regulated by the dramatic changes to chromatin structure that accompany cellular senescence.
RESEARCH HIGHLIGHTS Top Stem cells: Signalling to DNA methylation p595 | doi:10.1038/nrg3556 PDF Molecular evolution: Adaptation by loss of function p596 | doi:10.1038/nrg3557 PDF Gene expression: A cycle route to transcriptional noise p596 | doi:10.1038/nrg3558 PDF Genome stability: Specialist responses at telomeres p597 | doi:10.1038/nrg3559 PDF Evolution: Speciation meets microbiomes p598 | doi:10.1038/nrg3560 PDF Non-coding RNA: Structure and function for lncRNAs p598 | doi:10.1038/nrg3561 PDF Development: Replication factors make the transition p598 | doi:10.1038/nrg3562 PDF IN BRIEF Gene therapy: Diluting the immune response with decoys | Transcriptomics: In situ RNA-seq | Complex disease: Meta-analysis for rare variants | Evolution: Genetic hitch-hiking prevalence | Model organisms: Systematic mouse-mutant characterization | Epigenetics: Understanding resistance to cancer drugs | Human genetics: Local ancestry inference gets faster and better | Technology: CRISPR tool for regulating gene expression PDF Genetics JOBS of the week Postdoc in Bioinformatics / Developmental Genetics Max Planck Institute for Molecular Genetics Posdoctoral / Project Scientist University of California, Davis Post-doctoral Fellow Institute of Genetics and Development of Rennes, France Postdoctoral Positions in Eye and Brain Development St. Jude Children's Research Hospital, Memphis, Tennessee, USA Postdoc Position: Molecular Mechanisms of Specific Synapse Formation VIB Center for the Biology of Disease, K.U.Leuven More Science jobs from Genetics EVENT Malaria Experimental Genetics 09.02.14 Cambridge, UK More science events from
PROGRESS		Top
Omics technologies and the study of human ageing Ana M. Valdes, Daniel Glass & Tim D. Spector p601 | doi:10.1038/nrg3553 High-throughput technologies are starting to be applied to assess the complex molecular changes that occur with increasing age in humans. This Progress article introduces the emerging findings for transcriptomics, epigenomics, metabolomics and other 'omics' approaches. Abstract | Full Text | PDF
REVIEWS		Top
Genomic imprinting and parent-of-origin effects on complex traits Heather A. Lawson, James M. Cheverud & Jason B. Wolf p609 | doi:10.1038/nrg3543 Increasing evidence suggests that parent-of-origin effects, particularly genomic imprinting, contribute to complex traits. This Review discusses how such effects can be identified in order to expand our understanding of their roles in phenotypes such as human diseases and traits important for agriculture. Abstract | Full Text | PDF
Article series: Applications of next-generation sequencing Single-cell sequencing-based technologies will revolutionize whole-organism science Ehud Shapiro, Tamir Biezuner & Sten Linnarsson p618 | doi:10.1038/nrg3542 Technologies that are based on next-generation sequencing are increasingly being used to study individual cells. The authors discuss the application of this approach to single-cell genomics and transcriptomics, and explore the implications for both basic research and medicine. Abstract | Full Text | PDF
Spatiotemporal signalling in plant development Erin Sparks, Guy Wachsman & Philip N. Benfey p631 | doi:10.1038/nrg3541 This Review considers mechanisms by which information is transmitted over short and long distances during plant development and how different modes of signalling integrate with gene regulatory networks to allow plants to respond to their environment. Abstract | Full Text | PDF
New genes as drivers of phenotypic evolution Sidi Chen, Benjamin H. Krinsky & Manyuan Long p645 | doi:10.1038/nrg3521 Genes that have originated in recent evolution are present in only a subset of organisms and are often assumed to be dispensable or redundant. This Review discusses our latest understanding of how new genes in diverse species have actually evolved to have important functions in diverse developmental and physiological processes in various organisms. Abstract | Full Text | PDF
ANALYSIS		Top
Article series: Disease mechanisms Genetic insights into common pathways and complex relationships among immune-mediated diseases Miles Parkes, Adrian Cortes, David A. van Heel & Matthew A. Brown p661 | doi:10.1038/nrg3502 Research into the genetics of immune and inflammatory disease has experienced major recent advances owing to the availability of a custom single-nucleotide polymorphism (SNP) genotyping array — the Immunochip — developed specifically to investigate these disorders. In this Analysis, the authors assess findings from studies that have used this platform, and explore the shared and phenotype-specific genetic associations among several immune-mediated diseases. Abstract | Full Text | PDF | Supplementary information
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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