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Kui Yang, Yunsheng Liu, Zhixiong Liu et al.
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| | The
objective of this study was to confirm the biological role of p38γ in
human gliomas. The expression profiles of p38γ and hTERT in human glioma
samples were detected by Western … | |
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Erik Keimpema, Alán Alpár, Fiona Howell et al.
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| | Endocannabinoids
are small signaling lipids, with 2-arachidonoylglycerol (2-AG)
implicated in modulating axonal growth and synaptic plasticity. The
concept of short-range … | |
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Jun Sugimoto, Makiko Sugimoto, Helene Bernstein et al.
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Zufeng Ding, Shijie Liu, Changqing Sun et al.
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| | Here
we demonstrate that “concentration polarization” of ox-LDL enhances
LOX-1 expression and ox-LDL uptake. It damages cell surface heparan
sulfate proteoglycans (HSPG) and … | |
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Kevin D'Ostilio, Julien Cremers, Valérie Delvaux et al.
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| | While
it is increasingly recognized that voluntary movements are produced by
an interaction between conscious and unconscious processes, the role of
the latter in Parkinson's … | |
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Carole Gauron, Christine Rampon, Mohamed Bouzaffour et al.
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| | A
major issue in regenerative medicine is the role of injury in promoting
cell plasticity. Here we explore the function of reactive oxygen
species (ROS) induced through lesions in … | |
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Lesley J. Rogers, Elisa Rigosi, Elisa Frasnelli et al.
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| | Sophisticated
cognitive abilities have been documented in honeybees, possibly an
aspect of their complex sociality. In vertebrates brain asymmetry
enhances cognition and … | |
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Hirotaka Nakayama, Atsushi Shiraki, Ryuji Hirayama et al.
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Tae-Rin Lee, Myunghwan Choi, Adrian M. Kopacz et al.
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| | Although
most nanofabrication techniques can control nano/micro particle (NMP)
size over a wide range, the majority of NMPs for biomedical applications
exhibits a diameter of … | |
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Cesar A. López, Alex H. de Vries, Siewert J. Marrink
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| | Beta-cyclodextrins (β-CDs)
can form inclusion complexes with cholesterol, and are commonly used to
manipulate cholesterol levels of biomembranes. In this work, we have
used … | |
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Jakob Dogan, Xin Mu, Åke Engström et al.
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| | Intrinsically
disordered proteins are abundant in the eukaryotic proteome, and they
are implicated in a range of different diseases. However, there is a
paucity of experimental … | |
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Fei Zhu, Xiaobo Zhang
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| | Phagocytosis
is crucial for triggering host defenses against invading pathogens in
animals. However, the receptors on phagocyte surface required for
phagocytosis of virus have not … | |
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Akiko Hida, Shingo Kitamura, Yosuke Ohsawa et al.
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| | Evaluation
of circadian phenotypes is crucial for understanding the
pathophysiology of diseases associated with disturbed biological rhythms
such as circadian rhythm sleep … | |
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Barbara Salani, Cecilia Marini, Alberto Del Rio et al.
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| | The
anti-hyperglycaemic drug metformin has important anticancer properties
as shown by the direct inhibition of cancer cells proliferation. Tumor
cells avidly use glucose as a … | |
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Michael Lierz, Matthias Reinschmidt, Heiner Müller et al.
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| | The
paper described a novel technique for semen collection in large
psittacines (patent pending), a procedure which was not routinely
possible before. For the first time, a large … | |
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Yuting Liu, Wenchao Hu, Yasuhiro Murakawa et al.
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| | The
body temperature is considered a universal cue by which the master
clock synchronizes the peripheral clocks in mammals, but the mechanism
is not fully understood. Here we … | |
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Gaurav Ahuja, Ivan Ivandić, Mehmet Saltürk et al.
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| | Crypt
neurons are a third type of olfactory receptor neurons with a highly
unusual “one cell type - one receptor” mode of expression, the same
receptor being expressed by the … | |
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Cui-Xia Xu, Yu-Xuan Zheng, Xiao-Hui Zheng et al.
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| | A quaternized trigeminal ligand, 4-[4,6-di(4-pyridyl)-1,3,5-(2-triazinyl)]-1-methylpyridine-1-ium hexafluorophosphate (dptmp·PF6), and two derivative V-shaped dinuclear Pt(II) … | |
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Piotr Religa, Renhai Cao, Dorota Religa et al.
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| | The
functional impact of amyloid peptides (Aβs) on the vascular system is
less understood despite these pathologic peptides are substantially
deposited in the brain vasculature of … | |
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Emma Killick, Richard Morgan, Francesca Launchbury et al.
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| | Controversy
surrounds the use of PSA as a biomarker for prostate cancer detection,
leaving an unmet need for a novel biomarker in this setting; urinary EN2
may identify … | |
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Haiyan Wu, Xiaoqin Mai, Honghong Tang et al.
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| | The
embodied view of language processing holds that language comprehension
involves the recruitment of sensorimotor information, as evidenced by
the somatotopic representation of … | |
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Sabrina Wend, Cristina Dal Bosco, Michael M. Kämpf et al.
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| | Time-resolved
quantitative analysis of auxin-mediated processes in plant cells is as
of yet limited. By applying a synergistic mammalian and plant synthetic
biology approach, we … | |
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Marcel A. Lauterbach, Marc Guillon, Asma Soltani et al.
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| | Stimulated
Emission Depletion (STED) microscopy enables superresolution imaging of
fluorescently marked nano-structures in vivo. Biological investigations
are often hindered by … | |
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Ryo Nakano, Takuma Takanashi, Annemarie Surlykke et al.
| |
| | Ultrasonic
mating signals in moths are argued to have evolved via exploitation of
the receivers' sensory bias towards bat echolocation calls. We have
demonstrated that female … | |
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Mathias Linkerhand, Claudius Gros
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| | Coupling
local, slowly adapting variables to an attractor network allows to
destabilize all attractors, turning them into attractor ruins. The
resulting attractor relict network … | |
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K. E. Plummer, S. Bearhop, D. I. Leech et al.
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| | Supplementation
of food to wild birds occurs on an enormous scale worldwide, and is
often cited as an exemplar of beneficial human-wildlife interaction.
Recently it has been … | |
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Prerna Malaney, Ravi Ramesh Pathak, Bin Xue et al.
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| | IDPs,
while structurally poor, are functionally rich by virtue of their
flexibility and modularity. However, how mutations in IDPs elicit
diseases, remain elusive. Herein, we have … | |
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Qiong Li, Daoxiang Zhang, Yongbin Wang et al.
| |
| | How
TGF-β1-mediated signaling pathways are finely tuned to orchestrate the
generation of carcinoma-associated fibroblasts (CAFs) is poorly
understood. Here, we demonstrate that … | |
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Laura Pancotto, Gabriella De Angelis, Esmeralda Bizzarri et al.
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| | Streptococcus pneumoniae
pili contribute to adherence and virulence. The regulation of pilus-1
expression is bistable, thus piliated strains contain a variable
proportion of … | |
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André Gergs, Armin Zenker, Volker Grimm et al.
| |
| | In
addition to natural stressors, populations are increasingly exposed to
chemical pollutants released into the environment. We experimentally
demonstrate the loss of resilience … | |
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Valentin Hagel, Markus Mateescu, Alexander Southan et al.
| |
| | We
designed bioinspired cross-linkers based on desmosine, the cross-linker
in natural elastin, to prepare hydrogels with thiolated hyaluronic
acid. These short, rigid … | |
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Yanling Zhang, Feng Fu, Te Wu et al.
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| | Amounts of empirical evidence, ranging from microbial cooperation to collective hunting, suggests public goods produced often nonlinearly depend on the total amount of … | |
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Nobuo Masataka, Leonid Perlovsky
| |
| | Debates
on the origins of consonance and dissonance in music have a long
history. While some scientists argue that consonance judgments are an
acquired competence based on … | |
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Yuichiro Saito, Jun Takeda, Masahiro Okada et al.
| |
| | Although
RAD52 plays a critical role in the initiation of homologous
recombination (HR) by facilitating the replacement of RPA with RAD51,
the mechanism controlling RAD52 remains … | |
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G. Papadakis, A. Tsortos, A. Kordas et al.
| |
| | Application
of PCR to multiplexing assays is not trivial; it requires multiple
fluorescent labels for amplicon detection and sophisticated software for
data interpretation. … | |
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A. Lintunen, T. Hölttä, M. Kulmala
| |
| | Water
in the xylem, the water transport system of plants, is vulnerable to
freezing and cavitation, i.e. to phase change from liquid to ice or
gaseous phase. The former is a … | |
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Stephanie Cacioppo, Chris Frum, Erik Asp e
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