Nature Reviews Molecular Cell Biology contents July 2013 Volume 14 Number 8 pp461-542

Advertisement
Get more out of your grant money! "Labguru makes the lab more organized, improves student research processes, saves time and reduces costs. My Labguru account is definitely money well spent." Rohan Teasdale, Associate Professor, The University of Queensland, Australia Purchase an annual account and get an additional 2 months FREE. To learn more, go to http://www.labguru.com/nature
TABLE OF CONTENTS
August 2013 Volume 14 Number 8
Impact Factor 37.162 *	In this issue Research Highlights Progress Reviews Also this month  Featured article: Unravelling stem cell dynamics by lineage tracing Cédric Blanpain & Benjamin D. Simons
Subscribe   Facebook   RSS   Recommend to library   Twitter
Advertisement
Frontiers Research Topics  RTs enable you and your colleagues to drive your field where you want to take it, by encouraging dialogue and collaboration between researchers. A collection of papers in an evolving field around a topic that you choose. Papers submitted are rigorously peer-reviewed and freely available under a CC-BY license.  Your Topic - Your Way - Your Frontiers
RESEARCH HIGHLIGHTS Top Protein metabolism: Proteostasis goes global p461 | doi:10.1038/nrm3626 Two studies provide evidence of non-cell-autonomous control of proteostasis. PDF Cytoskeleton: Building actin networks on vesicles p462 | doi:10.1038/nrm3618 A vesicle-based mechanism to regulate the dynamics and density of intracellular actin networks. PDF Cell migration: Feeling the squeeze p462 | doi:10.1038/nrm3627 Cell migration through tight spaces becomes restricted by nuclear deformation. PDF Cell signalling: EGF signalling — it's all in SHC1's timing p463 | doi:10.1038/nrm3630 The timing of SHC1 phosphorylation events regulates the output of EGF signalling. PDF Chromatin: Limiting the DDR p464 | doi:10.1038/nrm3617 BRD4 inhibits the propagation of the DDR by recruiting a chromatin-condensing complex to acetylated histones. PDF Stem cells: Tailored splicing patterns p464 | doi:10.1038/nrm3621 MBNL proteins regulate alternative splicing events that affect pluripotency and reprogramming. PDF Cell migration: Collective cell courtship p466 | doi:10.1038/nrm3622 Different cell types engage in a 'chase-and-run' behaviour to drive collective cell migration. PDF JOURNAL CLUB There's more to lithium than Nirvana p466 | doi:10.1038/nrm3628 The discovery that GSK3β is a target of lithium. PDF IN BRIEF Stem cells: Promoting death | Cell growth: TORC1 coordinates cell growth and morphology | Translation: Recycling ribosomes | Autophagy: Eating up damaged lysosomes | Chromatin: Lysosomes help process chromatin in senescence | Protein metabolism: Cytosolic aggregates impair nuclear degradation PDF Molecular Cell Biology JOBS of the week Institute Assoc Scientist III - Molecular Biology MD Anderson Cancer Center Postdoctoral Fellow Position Massachusetts General Hospital Bioinformatics Postdoctoral Fellow: Human Epigenomic Variation in Development and Disease Genome Institute of Singapore, A*STAR Senior Research Technologist St. Jude Children's Research Hospital Postdoctoral position at the Johns Hopkins School of Medicine. Johns Hopkins School of Medicine More Science jobs from
PROGRESS		Top
Role of the extracellular matrix in regulating stem cell fate Fiona M. Watt & Wilhelm T. S. Huck p467 | doi:10.1038/nrm3620 The extracellular matrix (ECM) is a key component of the stem cell niche and is now emerging as more than just an inert scaffold. Indeed, new technologies have provided mechanistic insights into the effects of the ECM on stem cell fate choice. Abstract | Full Text | PDF
REVIEWS		Top
Diversifying microRNA sequence and function Stefan L. Ameres & Phillip D. Zamore p475 | doi:10.1038/nrm3611 The mechanisms that regulate miRNA stability and the generation of distinct miRNA isoforms are beginning to be elucidated. Better understanding of how such miRNAs mediate gene expression control will require quantitative analyses that dissect different models of miRNA function. Abstract | Full Text | PDF
Unravelling stem cell dynamics by lineage tracing Cédric Blanpain & Benjamin D. Simons p489 | doi:10.1038/nrm3625 Lineage-tracing and genetic labelling technologies, combined with statistical analyses of cell proliferation and clonal fate, provide powerful tools to study the mechanisms and dynamics of stem and progenitor cell fate determination in development and disease. Abstract | Full Text | PDF
Talins and kindlins: partners in integrin-mediated adhesion David A. Calderwood, Iain D. Campbell & David R. Critchley p503 | doi:10.1038/nrm3624 The ability of integrins to link the extracellular environment to intracellular networks enables cells to respond to chemical and physical cues. Insight has been gained into how talins and kindlins, two families of FERM-domain proteins that bind the cytoplasmic tail of integrins, mediate integrin activation and the cellular processes that depend on this. Abstract | Full Text | PDF
Control of cell cycle transcription during G1 and S phases Cosetta Bertoli, Jan M. Skotheim & Robertus A. M. de Bruin p518 | doi:10.1038/nrm3629 Recent work revealed new insights into the temporal regulation of G1-S cell cycle transcription, during proliferation and in response to activation of the DNA replication checkpoint. This has established the importance of G1-S transcription for both cell cycle progression and the maintenance of genome stability. Abstract | Full Text | PDF
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair Mei Xin, Eric N. Olson & Rhonda Bassel-Duby p529 | doi:10.1038/nrm3619 The adult mammalian heart has limited potential for regeneration and repair. Progress has been made in elucidating the cellular processes and regulatory mechanisms involved in heart growth and development, and this can be exploited to restore function in the injured adult heart. Abstract | Full Text | PDF
Corrigendum: Macrodomain-containing proteins: regulating new intracellular functions of mono(ADP-ribosyl)ation Karla L. H. Feijs, Alexandra H. Forst, Patricia Verheugd & Bernhard Lüscher p542 | doi:10.1038/nrm3623 Full Text | PDF
Advertisement
Nature Reprint Collection MicroRNAs from bench to clinic This Nature Reprint Collection presents some of the recent advances in moving microRNAs from basic research into the clinic both as diagnostic biomarkers and therapeutic targets.  Click here to access the Collection for free! Produced with support from:
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

*2011 Journal Citation Report (Thomson Reuters, 2012)

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.