Nature Immunology Contents: October 2013 Volume 14 pp 977 - 1100

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ReichertSPR.com  Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement The Role of HLA-C in Allogeneic Hematopoietic Cell Transplantation  Topic Editors: Effie W. Petersdorf and Antoine Toubert | Submission deadline: 15 Jan 2014 In this Research Topic from Frontiers in Immunology, the functional consequences of HLA-C diversity, its role in T and NK-mediated alloreactions that impact risks of acute and chronic GVHD and relapse after blood, marrow and cord blood transplantation, will be highlighted.  Find out more on how you can contribute to this Research Topic.   Focus Top Focus on Tissue-resident leukocytes Focus issue: October 2013 Volume 14 No 10 Contents Editorial Reviews Research Highlights Immune cells are found in diverse nonlymphoid tissues where they patrol against infection and injury and help to maintain homeostasis. This month's Focus features five specially commissioned Reviews that discuss interactions and functions of tissue-resident leukocytes. Editorial Top Focus on Tissue-resident leukocytes Immunity in the tissues   p977 doi:10.1038/ni.2722 Tissue-resident leukocytes contribute to tissue function and homeostasis as well as immune surveillance. Reviews Top Focus on Tissue-resident leukocytes The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells   pp978 - 985 William R Heath and Francis R Carbone doi:10.1038/ni.2680 The skin is a highly complex organ and the main body barrier against pathogens and other environmental factors. Heath and Carbone outline many of the innate and adaptive immune cell types associated with the skin. Focus on Tissue-resident leukocytes Tissue-resident macrophages   pp986 - 995 Luke C Davies, Stephen J Jenkins, Judith E Allen and Philip R Taylor doi:10.1038/ni.2705 Macrophages populate tissues under homeostatic conditions. Taylor and colleagues discuss the heterogeneity of tissue macrophage populations, and how they contribute to tissue function and immune surveillance. Focus on Tissue-resident leukocytes Immune surveillance by the liver   pp996 - 1006 Craig N Jenne and Paul Kubes doi:10.1038/ni.2691 The liver is important in mediating immunity to blood-borne infections. Jenne and Kubes review the liver as an immune organ and discuss the roles of liver-resident cells and their interactions with circulating immune cells. Focus on Tissue-resident leukocytes Regulatory T cells in nonlymphoid tissues   pp1007 - 1013 Dalia Burzyn, Christophe Benoist and Diane Mathis doi:10.1038/ni.2683 Regulatory T (Treg) cells modulate immune cell responses. Mathis and colleagues review the specialized roles played by tissue-specific Treg cells and reveal new functions that can be attributed to distinct Treg cell subsets. Focus on Tissue-resident leukocytes Innate and adaptive immune cells in the tumor microenvironment   pp1014 - 1022 Thomas F Gajewski, Hans Schreiber and Yang-Xin Fu doi:10.1038/ni.2703 Tumors can evade immune system-mediated destruction despite expressing antigenic neoepitopes. Gajewski, Schreiber and Fu discuss how the tumor microenvironment harnesses innate and adaptive immune cell regulatory processes to promote tumor survival. Research Highlights Top Focus on Tissue-resident leukocytes 'Short-term' residency | ILCs in liver pathology | Fate-mapping DCs | mTOR in Treg cells | Location is only part of the story | Holding a latent virus at bay Obituary Top Leo Lefrancois 1956-2013   p1024 Michael J Bevan doi:10.1038/ni.2706 Meeting Report Top Aegean reflections on innate immunity   pp1025 - 1029 George Hajishengallis, Alberto Mantovani, Alessandro Moretta and John D Lambris doi:10.1038/ni.2690 News and Views Top IL-1 signaling in atherosclerosis: sibling rivalry   pp1030 - 1032 Frederick J Sheedy and Kathryn J Moore doi:10.1038/ni.2711 Signaling via the interleukin 1 (IL-1) family, particularly by IL-1b, has long been linked to the pathogenesis of atherosclerosis. Findings that atherogenic fatty acids induce IL-1a to promote vascular inflammation identify a key role for this less-well-studied cytokine. See also: Article by Freigang et al. GATA-3 controls self-renewal in stressed HSCs   pp1032 - 1033 Toshimi Yoshida and Katia Georgopoulos doi:10.1038/ni.2715 The transcription factor GATA-3 is expressed in quiescent hematopoietic stem cells (HSCs) with long-term repopulating ability. Stress-mediated activation of HSCs promotes localization of GATA-3 to the nucleus in a manner dependent on the mitogen-activated protein kinase p38α and restricts self-renewal. See also: Article by Frelin et al. Fingerprinting Ikaros   pp1034 - 1035 Fotini Gounari and Barbara L Kee doi:10.1038/ni.2709 Zinc fingers 1 and 4 of Ikaros have unique functions in the selection of Ikaros target genes, lymphocyte development and the suppression of leukemogenesis. See also: Article by Schjerven et al. Immunology JOBS of the week Faculty Position in Virology Department of Microbiology-Immunology Northwestern University Tenure - Track Faculty Position in Immunology University of Massachusetts Tenure-Track Faculty Positions in the Department of Biochemistry, Microbiology and Immunology University of Ottawa, Faculty of Medicine Postdoc in Cancer Immunology, Harvard Medical School Dana-Farber Cancer Institute / Harvard Medical School Postdoctoral Fellowship in Retroviral Immunology National Institute of Allergy & Infectious Diseases (NIAID) More Science jobs from Immunology EVENT Tumor Immunology and Immunotherapy 28th Oct - 1st Nov 2013 Suzhou, China More science events from Research Highlights Top Sins of the mother | Plaques keep it local | From lung to gut | Becoming adaptive | lncRNAs in immune cells | Blocking transcription Articles Top GATA-3 regulates the self-renewal of long-term hematopoietic stem cells   pp1037 - 1044 Catherine Frelin, Robert Herrington, Salima Janmohamed, Mary Barbara, Gary Tran et al. doi:10.1038/ni.2692 Although GATA-3 is expressed in hematopoietic stem cells, its function there remains unclear. Iscove and colleagues show that GATA-3 inhibits the self-renewal potential of long-term hematopoietic stem cells downstream of p38 signaling. See also: News and Views by Yoshida & Georgopoulos Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis   pp1045 - 1053 Stefan Freigang, Franziska Ampenberger, Adrienne Weiss, Thirumala-Devi Kanneganti, Yoichiro Iwakura et al. doi:10.1038/ni.2704 Chronic inflammation is a fundamental aspect of metabolic disorders such as atherosclerosis. Freigang and colleagues report that fatty acids are potent inducers of IL-1α, which drives vascular inflammation. See also: News and Views by Sheedy & Moore IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39   pp1054 - 1063 Ivan D Mascanfroni, Ada Yeste, Silvio M Vieira, Evan J Burns, Bonny Patel et al. doi:10.1038/ni.2695 The immunoregulatory effect of IL-27 is thought to act mainly on T cells. Quintana and colleagues show that IL-27 also converts conventional DCs into immunosuppressive cells. Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch   pp1064 - 1072 Patrick M Gubser, Glenn R Bantug, Leyla Razik, Marco Fischer, Sarah Dimeloe et al. doi:10.1038/ni.2687 Effector memory CD8+ T cells are capable of rapid IFN-γ production. Hess and colleagues show that antigenic reactivation triggers enhanced glycolytic flux, which is required for early IFN-γ recall responses. Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros   pp1073 - 1083 Hilde Schjerven, Jami McLaughlin, Teresita L Arenzana, Seth Frietze, Donghui Cheng et al. doi:10.1038/ni.2707 The transcription factor Ikaros, which is essential for lymphocyte development, contains multiple zinc fingers. Smale and colleagues show that mice lacking different zinc fingers develop distinct lymphocyte-developmental defects and tumor susceptibility. See also: News and Views by Gounari & Kee MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma   pp1084 - 1092 Carol Y Ying, David Dominguez-Sola, Melissa Fabi, Ivo C Lorenz, Shafinaz Hussein et al. doi:10.1038/ni.2688 Diffuse large B cell lymphomas can arise from dysregulation of BCL6 expression. Dalla-Favera and colleagues show that the transcription factor MEF2B regulates BCL6 and is commonly associated with the generation of such lymphomas. Research Top Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets   pp1093 - 1100 Nina Schmolka, Karine Serre, Ana R Grosso, Margarida Rei, Daniel J Pennington et al. doi:10.1038/ni.2702 Silva-Santos and colleagues use genome-wide characterization of the methylation patterns of histone H3 and analysis of transcription factor expression to identify the regulatory framework of peripheral interferon-γ-producing or interleukin 17-producing γδ T cell subsets. 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