Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 10 Issue 8

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TABLE OF CONTENTS
August 2013 Volume 10 Number 8
Impact Factor 10.426*	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Featured article: Advances in motility testing—current and novel approaches Albert J. Bredenoord & André J. P.M. Smout
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RESEARCH HIGHLIGHTS Top Cancer: Importance of oncofetal gene, SALL4, in a subset of hepatocellular carcinoma Published online: 25 June 2013 p441 | doi:10.1038/nrgastro.2013.115 PDF Gut microbiota: Obesity-induced microbial metabolite promotes HCC Published online: 02 July 2013 p442 | doi:10.1038/nrgastro.2013.121 PDF Viral hepatitis: New strategy by which HCV evades host immune defences Published online: 09 July 2013 p443 | doi:10.1038/nrgastro.2013.127 PDF Regenerative medicine: Functional miniature human liver generated from stem cells Published online: 16 July 2013 p443 | doi:10.1038/nrgastro.2013.128 PDF Gallbladder: High levels of bilirubin as a risk factor for symptomatic gallstone disease Published online: 25 June 2013 p444 | doi:10.1038/nrgastro.2013.116 PDF Genetics: ADRB2 polymorphism predicts FGID diagnoses and quality of life Published online: 09 July 2013 p444 | doi:10.1038/nrgastro.2013.126 PDF Transplantation: ADORA2B helps to block liver injury Published online: 16 July 2013 p444 | doi:10.1038/nrgastro.2013.129 PDF IN BRIEF Liver: How caffeine affects liver fibrosis is revealed | Crohn's disease: Azathioprine is not better than placebo | Colorectal cancer: Low doses of aspirin reduce risk of colorectal cancer | Screening: Risk factors in patients undergoing CT colonography PDF Gastroenterology & Hepatology JOBS of the week Research Technician EMBL (European Molecular Biology Laboratory) Postdoctoral Research Position The Ohio State University College of Medicine Research Associate UCL Junior Research / Travel Fellowships The Kay Kendall Leukaemia Fund Research Associate, Basic Sciences Fred Hutchinson Cancer Research Center Research Asst I MD Anderson Cancer Center Post Doctoral Research Fellow University of Canterbury, New Zealand Junior Research Group University of Tübingen, Faculty of Medicine Clinical Trials Associate Lunenfeld - Tanenbaum Research Institute Researcher and Instructor Koc University School of Medicine More Science jobs from Gastroenterology & Hepatology EVENT Enhanced rare cell analysis – Visualize the invisible 30.10.13 Germany, Cologne More science events from
NEWS AND VIEWS		Top
Pancreas: Reconstruction methods after pancreaticoduodenectomy Giuseppe Malleo & Claudio Bassi Published online: 25 June 2013 p445 | doi:10.1038/nrgastro.2013.114 Pancreaticojejunostomy and pancreaticogastrostomy are both used for reconstruction after pancreaticoduodenectomy; which method is best is still debated. A nationwide multicentre randomized clinical trial that compared these two types of reconstruction has demonstrated that pancreaticogastrostomy is associated with a substantially lower rate of clinically relevant postoperative pancreatic fistula than pancreaticojejunostomy. Full Text | PDF
IBD: Antibodies to anti-TNF therapy—consequences for IBD management Welmoed K. van Deen & Daniel W. Hommes Published online: 02 July 2013 p446 | doi:10.1038/nrgastro.2013.118 Anti-TNF agents are effective drugs available for IBD treatment. However, antibody formation against these drugs hampers clinical effectiveness and increases risk of drug reactions. Knowledge on antibody kinetics and antibody testing is of critical importance to make well-informed decisions about starting, continuing, discontinuing and restarting of anti-TNF agents. Full Text | PDF
GERD: Surgery or medical therapy for patients with GERD? Carla Maradey & Ronnie Fass Published online: 09 July 2013 p448 | doi:10.1038/nrgastro.2013.123 The main therapeutic strategies for GERD are antireflux surgery and pharmacological intervention. The vast majority of patients with GERD receive or prefer medical over surgical therapy. A recent study compared minimal access surgery with medical management and provided 5-year follow up data. Full Text | PDF
Transplantation: Partial liver grafts are safe for young children Bruno Gridelli Published online: 09 July 2013 p450 | doi:10.1038/nrgastro.2013.124 The evolution in surgical technique has somewhat bridged the chasm between need and availability of liver grafts for young children. This study, using data on >2,600 liver transplantations in children <2 years of age from the United Network of Organ Sharing, shows that partial grafts from deceased donors can provide outcomes on par with whole livers. Full Text | PDF
REVIEWS		Top
Tumour progression and liver regeneration—insights from animal models Chetana Lim, Francois Cauchy, Daniel Azoulay, Olivier Farges, Maxime Ronot & Marc Pocard Published online: 09 April 2013 p452 | doi:10.1038/nrgastro.2013.55 Compelling evidence indicates that liver regeneration after portal vein occlusion and liver resection promotes tumour progression in patients with colorectal liver metastases. Here, the authors present clinical and experimental data from animal models of colorectal liver metastases pertaining to whether liver regeneration causes proliferation of tumour cells. Abstract | Full Text | PDF
Advances in motility testing—current and novel approaches Albert J. Bredenoord & André J. P. M. Smout Published online: 07 May 2013 p463 | doi:10.1038/nrgastro.2013.80 Gastrointestinal motility disorders are common in clinical practice. In this Review, the authors present an overview of the currently available gastrointestinal motility and function tests that are used to establish a diagnosis of functional disorders. Abstract | Full Text | PDF
Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets Gary M. Mawe & Jill M. Hoffman Published online: 25 June 2013 p473 | doi:10.1038/nrgastro.2013.105 Serotonin (5-HT) has been recognized for decades as an important signalling molecule in the gut, but it is still revealing its secrets. Mawe and Hoffman outline the conventional and nonconventional actions of 5-HT, and describe potential therapeutic strategies targeting this molecule and its receptors. Abstract | Full Text | PDF
Genetics and alcoholism Howard J. Edenberg & Tatiana Foroud Published online: 28 May 2013 p487 | doi:10.1038/nrgastro.2013.86 Excessive consumption of alcohol can have serious physical, psychological and social implications. Alcohol dependence is a complex genetic disease, with variants in many different genes affecting a person's risk of becoming dependent on alcohol. Here, the authors discuss the genetic factors underlying this disorder. Abstract | Full Text | PDF
PERSPECTIVES		Top
VIEWPOINT Helicobacter pylori research: historical insights and future directions Kwong Ming Fock, David Y. Graham & Peter Malfertheiner Published online: 11 June 2013 p495 | doi:10.1038/nrgastro.2013.96 The association of Helicobacter pylori infection with peptic ulcers was published in 1984. Here, Kwong Ming Fock, David Y. Graham and Peter Malfertheiner provide their insights into the advances in H. pylori research over the past 30 years and where research should be targeted in the future. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2011. Nature Reviews Gastroenterology & Hepatology was previously published as Nature Clinical Practice Gastroenterology & Hepatology.

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